 |
 |
 |
 |
 |
 |
|
Member Profiles: Group Leaders: Lab Members: |
|
 |
|
 |
Laboratory Members
Prof T.J. (Jack) Martin
AO MD DSC FRACP FRCPA FAA FRSJohn Holt Fellow, Emeritus Professor of Medicine
Bone, Joint & Cancer Unit
St Vincent's Institute
Telephone: +61 3 9288 2480
Facsimile: +61 3 9416 2676
Email: jmartin@svi.edu.au
Previous Positions:
| 1988-2002 | Director of St Vincent's Institute |
| 1977-present | Professor of Medicine, University of Melbourne |
| until 1988 | Austin/Repatriation Hospitals |
| St Vincent's/Geelong Hospitals | |
| 1974-1977 | Professor of Chemical Pathology, University of Sheffield, U.K. |
Education:
| 1960 | M.B.B.S., Melbourne University |
| 1969 | M.D. |
| 1979 | D.Sc. |
| 1992 | M.D.(Hon.Causa), Sheffield University |
| FRACP | |
| FRCPA | |
| 1998 | FAA |
| 2000 | FRS |
Awards:
| 1971 | Selwyn Smith Prize for Medical Research (shared with C.I.Johnston). |
| 1974 | Eric Susman Prize (RACP). |
| 1982 | Yamagiwa-Yoshida Memorial International Study Grant. |
| 1988 | Chemofux Research Prize. |
| Matheson Lecturer, University of Melbourne . | |
| 1990 | Roman Lecturer, Australian Association of Clinical Biochemists. |
| Lemberg Medalist and Lecturer, Australian Biochemical Society. | |
| Clinical Endocrinology Trust Medal and Lecturer | |
| 1992 | Dale Medal, Society for Endocrinology , U.K. |
| 1994 | William F. Neuman Award, American Society for Bone and Mineral Research. |
| 1996 | Officer in the Order of Australia (AO), Queen's Birthday Honours. |
| 1998 | Fellow of the Australian Academy of Science. |
| 2000 | Fellow of the Royal Society. |
| 2003 | IBMS Pieter Gaillard Award. |
| 2004 | Ramaciotti Medal and Award. |
Scientific Involvement:
| 1972 | President, Australian Society for Medical Research, |
| 1969-1972 | Secretary, Endocrine Society of Australia |
| 1986-1989 | Vice-President, ICCRH (now IBMS) |
| 1989-1992 | President, ICCRH |
| 1987-1990 | Member of Council, American Society for Bone and Mineral Research |
| 1993-1996 | Founding President, ANZBMS |
| 1989-1998 | Chairman, Medical and Scientific Committee, Anti-Cancer Council of Victoria |
Editorial
| Associate Editor, "Bone" (Elsevier). | |
| Editorial Board, "Trends in Endocrinology and Metabolism" | |
| Editorial Board, "The Scientific World". |
Research Interests:
Endocrinology; cell biology; bone diseases.
Bone cell biology:
The differentiation of osteoblasts and osteoclasts, and how these processes are controlled by cytokines and growth factors in bone and by circulating hormones; how bone cells communicate with each other and with cells of the immune system; the genetic influences on bone cells.
Hormonal regulation of bone and calcium metabolism:
The hormones that influence bone cell function and calcium homeostasis, particularly parathyroid hormone (PTH), PTHrP, vitamin D, calcitonin and estrogen.
Diseases of bone:
Mechanisms of metastasis of cancers to bone, and the involvement of osteoclasts in this process; mechanisms leading to the development of osteoporosis. Approaches to the development of new drugs for the prevention and treatment of bone diseases.
Representative publications from a total of 380 original papers, 155 reviews, chapters and editorials, and 8 books:
- Ma YL, Cain RL, Halladay DL, Yang X, Zeng Q, Miles RR, Chandrasekhar S, Martin TJ, Onyia JE. Catabolic effects of continuous human PTH(1-38) iin vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 142:4047- 4054, 2001.
- Lam MH, Thomas RJ, Loveland KL, Schilderrs S, Gu M, Martin TJ, Gillespie MT, Jans DA. Nuclear transport of parathyroid hormone (PTH) related protein is dependent on microtubules. Mol Endocrinol. 16: 390-401, 2002
- Romas E, Gillespie MT, Martin TJ. Involvement of receptor activator of Nf kappa B ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. Bone 30: 340-6, 2002.
- Martin TJ. Manipulating the environment for cancer cells in bone; a novel therapeutic approach. J Clin Invest 110:1399-1401, 2002.
- Allan EH, Ho PW, Umezawa A, Hata J, Makishima F, Gillespie MT, Martin TJ. Differentiation potential of a mouse bone marrow stromal cell line. Journal of Cellular Biochemistry 90:158-69, 2003
- Mirosavljevic D, Quinn JM, Elliott J, Horwood NJ, Martin TJ, Gillespie MT. T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis. Journal of Bone and Mineral Research. 18:984-93, 2003.
- Sims NA, Jenkins BJ, Quinn JMW, Glatt M, Gillespie MT, Ernst M and Martin TJ. Gp130 regulates bone turnover and bone size by distinct downstream signalling pathways. Journal of Clinical Investigation 113:379-389, 2004.
- Onyia JE, Galvin RJS, Ma YL, Halladay DL, Miles RR, Yang X, Fuson TR, Cain RL, Zeng QQ, Chandrasekhar S, Emkey R, Xu Y, Thirunavukkarasu K, Bryant H , Martin TJ. Novel and selective small molecule inhibitors of osteoprotegerin expression inhibit bone resorption. Journal of Pharmacology and Experimental Therapeutics 309:369-379, 2004.
- Hausler K, Horwood NJ, Chuman Y, Fisher JL, Ellis J, Martin TJ, Rubin JS, Gillespie MT. Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. Journal of Bone and Mineral Research 19:1873-1881, 2004.
- Martin TJ. Paracrine regulation of osteoclast formation and activity: Milestones in discovery. Journal of Musculoskeletal and Neuronal Interactions. 4: 243-253, 2004
- Martin TJ, Sims NA. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends in Molecular Medicine. 11:76-81, 2005
- Karsdal MA, Henriksen K, Sorensen MG, Gram J, Schaller S, Dziegiel MH, Heegard AM, Christophersen P, Martin TJ, Christiansen C, Bollerslev J. Acidification of the osteoclast resorption compartment provides insight into the coupling of bone formation to bone resorption. American Journal of Pathology 166:467-476, 2005
- Bilezikian JP, Raisz LG and Martin TJ. (Editors). Osteoporosis. Principles of Bone Biology , Third edition. Elsevier. ISBN 13-978-0-12-373884-4. Pp 1942, 2008.. Martin TJ, Seeman E. New mechanisms and targets in the treatment of bone fragility. Clinical Science 112: 77-89, 2007.
- Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nisina H, Takeda S, Takanayagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 130:811-823, 2007.
- Kulkarni NH, Wei T, Kumar A, Dow ER, Stewart TR, Shou J, Ncho M, Sterchi DL, Gitter BD, Higgs RE, Halladay DL, Engler TA, Martin TJ, Bryant HU. Ma YL, Onyia JE. Changs in osteoblast, chondrocyte and adipocyte lineages mediate the bone anabolic actions of PTH and small molecule GSK-3 inhibitor. J Cell Biochem 102:1504-1528, 2007.
- Martin TJ, Sims NA, Ng KW. Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis. Osteoporosis International 19:1125-1138, 2008.
- Susperregui AR, Vinals F, Ho PW, Gillespie MT, Martin TJ, Ventura F. BMP-2 down-regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells. J Cell Physiol 216:144-152, 2008.
- Allan EH, Hausler KD, Wei T, Gooi JH, Quinn JM, Crimeen-Irwin B, Pompolo S. Sims NA, Gillespie MT, Onyia JE, Martin TJ. EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts. J Bone Min Res 23:1170-1181, 2008.
