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Laboratory Members
Prof Michael W. Parker
Associate Director
Biota Structural Biology Laboratory
St Vincent's Institute
Telephone: +61 3 9288 2499
Facsimile: +61 3 9416 2676
Email: mparker@svi.edu.au
Other Positions:
- Head, Biota Structural Biology Laboratory, St. Vincent's Institute
- Professorial Fellow and Professor, Department of Biochemistry and Molecular Biology, University of Melbourne
- National Health & Medical Research Council Senior Principal Research Fellow
Education:
| 1980 | B. Sc. (Hons.), Australian National University |
| 1985 | D. Phil., Oxford University |
Previous Positions:
| 2000 - 2001 | Australian Research Council Professorial Research Fellow |
| 1998 - 2001 | Principal Fellow and Associate Professor at the Department of Biochemistry and Molecular Biology, University of Melbourne |
| 1996 - 2000 | Australian Research Council Senior Research Fellow at St. Vincent's Institute |
| 1991 - 1996 | Welcome Australian Senior Research Fellow at St. Vincent's Institute |
| 1986 - 1991 | Staff Scientist at the European Molecular Biology Laboratory, Heidelberg, Germany |
Awards:
| 1991 | Welcome Trust Senior Research Fellowship |
| 1994 | Selwyn-Smith Medical Research Prize of Melbourne University |
| 1996 | Boehringer-Mannheim Medallist of the Australian Society for Biochemistry and Molecular Biology |
| 1997 | Australian Research Council Senior Research Fellowship |
| 1999 | Gottschalk Medal of the Australian Academy of Science. |
| 2001 | National Health & Medical Research Council Senior Principal Research Fellowship |
| 2002 | Royal Society of New South Wales Walter Burfitt Prize |
| 2004 | GE Healthcare Bio-Sciences Award of the Australian Society of Biochemistry and Molecular Biology |
| 2006 | Australian Research Council Federation Fellow |
Scientific Involvement:
| 1994 - 2000 | Scientific Advisory Board, Biota Holdings Ltd. |
| 1999 - 2002 | Chair (1999-2000) and member of the Executive Committee of the Australian Synchrotron Research Program |
| 1999- | Chairman (1999-2002) and member of the BioCARS Sub-Committee of the Australian Synchrotron Research Program |
| 1999 - 2002 | Member of the Industrial Synchrotron Roundtable (Victoria) |
| 1999 - 2001 | Council Member and Victorian State Representative of the Australian Society for Biochemistry and Molecular Biology |
| 1999 - 2001 | Member of the National Health & Medical Research Council of Australia Discipline Panel for Biochemistry |
| 2001 - | Member of the Lorne Protein Organizing Committee |
| 2003 | Member of the Bio21 Scientific Advisory Council |
Editorial
| 1998 - 2003 | Protein Science |
Research Interests:
Protein crystallography; structure-based drug design; cancer; infection; neurobiology.
The Biota Structural Biology Laboratory is focused on three disease areas: cancer, infection (bacterial toxins and viruses) and neurological diseases (Alzheimer's disease, memory loss, epilepsy, anxiety). Our aim is to understand the function of key proteins at a molecular level and to discover small molecules that alter the function of these proteins which may then be developed into clinically useful drugs. The lab uses a wide array of platform technologies including molecular biology, protein chemistry, X-ray crystallography, electrophysiology, virtual screening and structure-based drug design.
Representative publications from a total of 145 original papers, 39 reviews, chapters and editorials, and 1 book:
- Parker, M.W., Pattus, F., Tucker, A.D. and Tsernoglou, D. (1989) Structure of the membrane-pore-forming fragment of colicin A. Nature, 337, 93-96.
- Parker, M.W., Buckley, J.T., Postma, J.P.M., Tucker, A.D., Leonard, K., Pattus, F. and Tsernoglou, D. (1994) Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states. Nature, 367, 292-295.
- Hu, S-H, Parker, M.W., Lei, J-Y, Wilce, M.C.J., Benian, G.M. and Kemp, B.E. (1994) Insights into autoregulation from the crystal structure of twitchin kinase. Nature, 369, 581-584.
- Heierhorst, J., Kobe, B., Feil, S.C., Parker, M.W., Benian, G.M., Weiss, K.R. & Kemp, B.E. (1996) Ca2+/S100 regulation of giant protein kinases. Nature, 380, 636-639.
- Rossjohn, J., Feil, S.C., McKinstry, W.J., Tweten, R.K. & Parker, M.W. (1997) Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form. Cell, 89, 685-692.
- Rossjohn, J., Cappai, R., Feil, S.C., Henry, A., McKinstry, W.J., Galatis, D., Hesse, L., Multhaup, G., Beyreuther, K., Masters, C.L. & Parker, M.W. (1999) Crystal structure of the N-terminal, growth factor-like domain of Alzheimer's amyloid precursor protein. Nature Struct. Biol., 6, 327-331.
- Shatursky, O., Heuck, A.P., Shepard, L.A., Rossjohn, J., Parker, M.W., Johnson, A.E. & Tweten, R.K. (1999) The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins. Cell, 99, 293-299.
- Gilbert, R.J.C., JimīŋŠnez, J.L., Chen, S., Tickle, I., Rossjohn, J., Parker, M.W., Andrew, P.W. & Saibil, H. (1999) Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae. Cell, 97, 647-655.
- Polekhina, G., House, C.M., Traficante, N., Mackay, J.P., Relaix, F., Sassoon, D.A., Parker, M.W. & Bowtell, D.D.L. (2002) The Siah ubiquitin ligase component is structurally related to TRAF proteins and functions in the TNF-signalling pathway. Nature Struct. Biol., 9, 68-75.
- Cromer, B.A., Morton, C.J. & Parker, M.W. (2002) Anxiety over GABAA receptor structure relieved by AchBP. Trends Biochem. Sci., 27, 280-287.
- Barnham, K., McKinstry, W.J., Multhaup, G., Galatis, D., Morton, C.J., Curtain, C.C., Williamson, N.A., White, A.R., Hinds, M.G., Norton, R.S., Beyreuther, K., Masters, C.L., Parker, M.W. & Cappai, R. (2003) Structure of the Alzheimers disease amyloid precursor protein copper binding domain: a regulator of neuronal copper homeostasis. J. Biol. Chem., 278, 17401-17407.
- Polekhina, G., Giddings, K.S., Tweten, R.K. & Parker, M.W. (2005) Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Proc. Natl. Acad. Sci. USA 102, 600-605.
- Parker, M.W. & Feil, S.C. (2005) Pore-forming protein toxins: from structure to function. Prog. Mol. Biol. Biophys. 88, 91-142.
