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Member Profiles: Group Leaders: Lab Members: |
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Laboratory Members
Dr Natalie A Sims
NHMRC Senior Research Fellow
Bone, Joint & Cancer Unit
St Vincent's Institute
Telephone: +61 3 9288 2555
Facsimile: +61 3 9416 2676
Email: nsims@svi.edu.au
Education:
| 1991 | B.Sc (Hons) The University of Adelaide, South Australia |
| 1995 | Ph.D., The University of Adelaide, South Australia |
Awards:
| 1991-1994 | Dawes Research Scholarship, Royal Adelaide Hospital |
| 1995 | Outstanding Research Award, St Vincent's Research Symposium, Sydney. |
| 1999 | Young Investigator Award, American Society of Bone and Mineral Research Annual Meeting, St. Louis, USA. |
| 2000 | Travel Award, American Society of Bone and Mineral Research Annual Meeting, Toronto, Canada |
| 2001-2002 | Gleghorn Research Fellowship, University of Melbourne |
| 2002 | Young Investigator Award, International Society of Bone Morphometry, IXth Congress, Edinburgh. |
| 2003-2008 | NHMRC Career Development Award (R.D.Wright fellowship) |
| 2003 | International Bone and Mineral Society/BONE Best Basic Science Paper Award |
| 2004 | Best Senior Investigator Presentation, Best Scientific Poster, St. Vincent's Research Week, Melbourne |
| 2006 | NHMRC Senior Research Fellowship |
Scientific Involvement:
| 1989- | Australian Society for Medical Research (ASMR) |
| 1990- | Australia and New Zealand Bone and Mineral Society (ANZBMS) |
| 1994- | American Society for Bone and Mineral Research (ASBMR) |
| 1994- | International Society of Bone Morphometry (ISBM) |
| 2000- | International Bone and Mineral Society (IBMS) |
| 2000- | 2005 ASMR Medical Research Week Committee |
Research Interests:
Research goal: to identify new pathways for treatment of bone disease by studying intercellular communication within the bone microenvironment, particularly the communication between osteoblasts (bone forming cells) and osteoclasts (bone resorbing cells).
Approaches used include histomorphometric and ex vivo cell culture analyses of knockout animals and animal models of destructive bone diseases, with particular emphasis on diseases of bone remodeling including osteoporosis as well as work on rheumatology and osteoarthritis.
Publications (representative from a total of 28 original papers, 3 reviews and 4 book chapters
- Martin T.J., Gooi, J.H., Sims, N.A.. Molecular mechanisms in coupling of bone formation to resorption. Critical Reviews in Eukaryotic Gene Expression. In Press.
- Sims, N.A., Gooi, J.H. Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption Seminars in Cell and Developmental Biology. In Press. http://dx.doi.org/10.1016/j.semcdb.2008.07.016 (IF: 6.482)
- Walker, E.C., McGregor, N.E., Poulton, I.J., Pompolo, S., Allan, E.A., Quinn, J.M.W., Gillespie, M.T., Martin, T.J., Sims, N.A. Cardiotrophin-1 is a locally-acting regulator of bone formation produced by osteoblasts. Journal of Bone and Mineral Research. In Press. DOI: 10.1359/JBMR.080706 (IF: 6.004)
- Quinn, J.M.W., Sims, N.A., Saleh, H., Mirosa, D., Thompson, K., Bouralexis, S., Walker, E.C., Martin, T.J., Gillespie, M.T. Interleukin-23 Inhibits Osteoclastogenesis Indirectly through Lymphocytes and is Required for the Maintenance of Bone Mass in Mice. Journal of Immunology. In Press.(IF: 6.068)
- Martin, T.J., Sims, N.A. On the coupling of bone formation to resorption. Trends in Molecular Medicine. 11:76-81, 2005. (IF: 7.497; 65 citations)
- Walkley, C.R., Shea, J.M., Sims, N.A., Purton, L.E., Orkin, S.H. pRb extrinsically regulates hematopoietic stem cells via myeloid cell bone marrow microenvironment interactions. Cell. 129:1081-95 (2007). Commentary on this article: Perry, J.M., Li, L., Cell 129:1045-1047. (IF: 29.887; 22 citations)
- Sims, N.A., Brennan, K., Spaliviero, J.A., Handelsman, D.J., Seibel, M.J. Perinatal testosterone surge is required for normal adult bone size, but not for normal bone remodeling. American Journal of Physiology: Endocrinology and Metabolism 2006 Mar;290(3):E456-62. (IF: 4.138; 4 citations)
- Sims, N.A., Jenkins, B.J., Nakamura, A., Quinn, J.M.W., Li, R., Gillespie, M.T., Ernst, M., Robb, L., Martin, T.J. Interleukin-11 receptor signaling is required for normal bone remodeling. (2005). Journal of Bone and Mineral Research. 20: 1093-1102 (IF: 6.604; 10 citations).
- Sims, N.A., Jenkins, B.J., Quinn, J.M.W., Glatt, M., Gillespie, M.T., Ernst, M., Martin, T.J. gp130 regulates bone turnover and bone size by distinct downstream signaling pathways Journal of Clinical Investigation 113, 379-389; 2004. (IF: 14.051). Selected for highlighting in the _In This Issue_ section. Photo-article in Nature Medicine 10:237; 2004.
- Sims, N.A., Green, J.R., Glatt, M., Schlict, S., Martin, T.J., Gillespie, M.T., Martin, T.J., Romas, E. (2004) Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis. Arthritis and Rheumatism. 50, 2338_2346. (IF: 7.379) Editorial on this article: Goldring SR, Gravallese EM (2004) Arth Rheum 50, 2044-2047.
- Sims, N.A., Dupont, S., Krust, A., Clement-Lacroix, P., Minet, D., Resche-Rigon, M., Gaillard-Kelly, M., Baron, R. (2002). Skeletal phenotypes of estrogen receptors a, b and double knockouts suggest a dual role for ERb in bone remodeling. Bone. 30,18-25. (IF: 3.755; 31 citations). Cover Article. Reviewed in Miller, C.P. (2002). Current Pharmaceutical Design 8,2089-2111. Runner up _Best Basic Research Paper_ - International Bone and Mineral Society 2003
- Romas, E., Sims, N.A., Hards, D., Lindsay, M., Ryan, P.F.J., Dunstan, C., Martin, T.J., Gillespie, M.T. (2002). Fc-Osteoprotegerin (Fc-OPG) fusion protein reduces osteoclast numbers and prevents bone destruction in rats with collagen-induced arthritis. American Journal of Pathology 162,1419-1427. (IF: 6.75; 35 citations).
- Sims, N.A., Cl￩ment-Lacroix, P., Minet, D., Fraslon-Vanhulle, C., Gaillard-Kelly, M., Resche-Rigon, M., Baron, R. (2003). A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in ER deficient mice. Journal of Clinical Investigation 111,1319-1327. (IF: 14.051; 10 citations).
- Calvi, L.M., Sims, N.A., Hunzelman, J.L., Knight, M.C., Giovannetti, A., Saxton, J.M., Baron, R., Kronenberg, H.M., Schipani, E. (2001). Activated parathyroid hormone / parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. Journal of Clinical Investigation 107,277-286 (IF: 14.051; 26 citations).
- Sabatakos, G.*, Sims, N.A.*, Chen, J., Aoki, K., Kelz, M., Amling, M., Bouali, Y., Mukhopadhyay, K., Ford, K., Nestler, E., Baron, R (2000). The transcription factor DFosB stimulates bone formation and inhibits adipogenesis. Nature Medicine 6:985-990. *,contributed equally. (IF: 28.740; 76 citations). Cover article. Commentary on this article: Karsenty G. Nature Medicine 6:970-971
- Marzia, M.*, Sims, N.A.*, Voit, S., Migliaccio, S., Taranta, A., Bernardini, S., Faraggiana, T., Yoneda, T., Mundy, G.R., Boyce, B.F., Baron, R., Teti, A. (2000). Decreased c-Src expression enhances osteoblast differentiation and bone formation. Journal of Cell Biology 151,311-320. *, contributed equally. (IF: 12.522; 35 citations).
- Sims, N.A., Clement-Lacroix, P., Da Ponte, F., Bouali, Y., Binart, N., Moriggl, R., Goffin, V., Coshigano, K., Gaillard-Kelly, M., Kopchick, J., Baron, R., Kelly, P.A (2000). Decreased bone turnover and growth in growth hormone receptor (GHR) null mice is reversible by IGF-I treatment but independent of Stat5. Journal of Clinical
