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Laboratory Members
Dr Boris Sarcevic
Unit Head
Cell Cycle and Cancer Unit
St Vincent's Institute
Telephone: +61 3 9288 2480
Facsimile: +61 3 9416 2676
Email: bsarcevic@svi.edu.au
Education:
| B.Sc (Hons) | |
| Ph.D |
Scientific Involvement (selected):
| Member, NH&MRC Grant Review Panel (2008) |
| ARC OzReader (2007, 2008) |
| Organising committee, Australian Cell Cycle Workshop (2002, 2006, 2008)(2007, 2008) |
Research Interests:
In higher eukaryotes, controlled cell proliferation and differentiation is required for normal growth and development. Deregulation of cell growth pathways leading to unrestrained cell division is a primary characteristic of cancerous cells. Therefore, defining the causes of increased cellular division is fundamental to understanding carcinogenesis. Our group is interested in understanding the molecular mechanisms of cell division and how deregulation of these pathways contributes to the development of human cancer. Our research ultimately aims to develop new approaches for cancer therapy.
Publications:
- Martin Sadowski, Rohan Baker, Amanda Mawson and Boris Sarcevic (2007) Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression Biochem. J. 405, 569-581
- Amanda Mawson, Angela Lai, Jason S. Carroll, C. Marcelo Sergio, Christopher J. Mitchell and Boris Sarcevic (2005) Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1 Molec. Cell. Endocrinol 229, 161-173
- Juliana Soosairajah, Sankar Maiti, ONeil Wiggan, Patrick Sarmiere, Nathalie Moussi, Boris Sarcevic, Rashmi Sampath, James R. Bamburg and Ora Bernard (2005) Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin EMBO J. 24, 473-486
- Timothy C.Tan, Valentina A. Valova, Chandsra S. Malladi, Mark E. Graham, Leise A. Berven, Orla J. Jupp, Gurdip Hansra, Sonya J. McClure, Boris Sarcevic, Ross A. Boadle, Martin R. Larsen, Michael A.Cousin and Phillip J. Robinson (2003) Cdk5 is essential for synaptic vesicle endocytosis Nat. Cell Biol. 5, 701-710
- Boris Sarcevic, Amanda Mawson, Rohan T. Baker and Robert L. Sutherland (2002) Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation EMBO J. 21, 2009-2018
- Zhonglin Chai, Boris Sarcevic, Amanda Mawson and Ban Hock Toh (2001) Set-related cell division autoantigen-1 (CDA1) arrests cell growth J. Biol. Chem. 276, 33665-33674
- Angela Lai, Boris Sarcevic, Owen Prall and Robert L. Sutherland (2001) Insulin/Insulin-like growth factor-I and estrogen cooperate to stimulate cyclin E/Cdk2 activation and cell cycle progression in MCF-7 breast cancer cells through differential regulation of cyclin E and p21WAF1/Cip1 J. Biol. Chem. 276, 25823-25833
- Brian Gabrielli, Boris Sarcevic, Joanne Sinnamon, Marina Castellano, Graeme Walker, Xue-Qing Wang and Kay Ellem. (1999) A cyclin D/cdk4 activity required for G2 phase cell cycle progression is inhibited in UV radiation-induced G2 phase delay. J. Biol. Chem. 274, 13961-13969
- Owen J. Prall, Boris Sarcevic, Elizabeth A. Musgrove, Colin K.W. Watts and Robert L. Sutherland. (1997) Estrogen-induced activation of Cdk4 and Cdk2 during G1-S Phase Progression Is Accompanied by Increased cyclin D1 Expression and Decreased Cyclin-dependent Kinase inhibitor Association with cyclin E-Cdk2. J. Biol. Chem. 272, 10882-10894
- Boris Sarcevic, Richard Lilischkis and Robert L. Sutherland (1997) Differential Phosphorylation of T-47D Human Breast Cancer Cell Substrates by D1-, D3-, E- and A-, Cyclin/CDK Complexes. J. Biol. Chem. 272, 33327-33337
- Boris Sarcevic, Eleanor Erikson and James L. Maller. (1993) Purification and Characterisation of a Mitogen-activated Protein Kinase Tyrosine Phosphatase from Xenopus Eggs. J. Biol. Chem. 268, 25075-25083
- Olivier Haccard, Boris Sarcevic, Andrea Lewellyn, Rebecca Hartley, Linda Roy, Tetsuro Izumi, Eleanor Erikson and James L. Maller. (1993) Induction of Metaphase Arrest in Cleaving Xenopus Embryos by MAP Kinase. Science 262, 1262-1265
- Boris Sarcevic, Victoria Brookes, Thomas J. Martin, Bruce E. Kemp, and Phillip J. Robinson. (1989) Atrial Natriuretic Peptide-dependent Phosphorylation of Smooth Muscle Cell Particulate Fraction Proteins is Mediated by cGMP-dependent Protein Kinase. J. Biol. Chem. 264, 20648-20654
