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Laboratory Members
Dr Ora Bernard
Group Leader
Cytoskeleton & Cancer Unit
St Vincent's Institute
Telephone: +61 3 9288 3253
Facsimile: +61 3 9416 2676
Email: obernard@svi.edu.au
Previous Positions:
| 1967-68 | Visiting Scientist, Institute de Recherche sur les maladie du sang, Hopital St. Louis Paris, Laboratory of Professor J Dausset |
| 1969 | Research Assistant, GD Searle Research Laboratories, High-Wycombe, UK |
| 1973 | Post Doctoral Fellow, The University of Melbourne, Microbiology |
| 1974-77 | Post Doctoral Fellow, Molecular Biology Unit, The Walter and Eliza Institute |
| 1977-79 | Member, The Basel Institute for Immunology |
| 1979-81 | Senior Research Officer, Molecular Biology Unit, WEHI |
| 1981-84 | Research Fellow, Molecular Biology Unit, WEHI |
| 1985 | On sabbatical leave, The Weizmann Institute of Science, Rehovot, Israel |
| 1986-94 | Senior Research Fellow, Head, Molecular Neurobiology Laboratory, Molecular Biology Unit, WEHI |
| 1994-2002 | Principal Research Fellow, Head, Molecular Neurobiology Laboratory, Development and Neurobiology group, WEHI |
| 2003-2005 | Principal Research Fellow, Laboratory Head, Molecular Genetics of Cancer Division, WEHI |
| 2006-present | Principal Research Fellow, Head of The Cytoskeleton and Cancer Laboratory, St. Vincent Institute of Medical Research |
Education:
| 1966 | MSc in Biochemistry and Microbiology, Tel-Aviv University, Israel. |
| 1973 | PhD in Biochemistry, McGill University, Montreal Canada. |
| 1996 | Master in Psychoanalytic Studies, Monash University. |
Awards:
| 1967-68 | The Minister of Cultural Affairs Fellowship, France |
| 1969-73 | Postgraduate Research Fellowship, MRC, Canada |
| 1973-76 | Postdoctoral Fellowship of the Canadian MRC |
| 1985 | Visiting Scientist Fellowship, The Weizmann Institute, Rehovot, Israel |
| 2001 | Visiting Scientist Fellowship, Shanghai Second Medical University, China |
Selected Publications:
- Dan C, Kelly A, BERNARD O, Minden A. Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J Biol Chem 276:32115-32121, 2001.
- Whitfield J, Neame, SJ, Paquet L, BERNARD O, Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29:629-643, 2001.
- Erickson RP and BERNARD O. Studies on Neuronal Death in the Mouse Model of Niemann-Pick C Disease. JNR, 68: 738-774, 2002
- Yoshioka K, Foletta V, BERNARD O and Itoh K. A role for LIM kinase in cancer metastasis. Proc Natl Acad Sci USA 100:7247-7252, 2003.
- Victoria C. Foletta, Mei Ann Lim, April P. Kelly, Edouard G. Stanley, Mark Shannon, Juliana Soosairajah, Wei He, Supratik Das, Joan Massagu￩ and ORA BERNARD. Direct signalling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J.Cell Biol 162: 1089-1098, 2003.
- Victoria Foletta, Nathalie Moussi, Patrick D. Sarmiere, James R. Bamburg and ORA BERNARD. LIM kinase 1, a key regulator of actin dynamics, is widely expressed in all tissues. Exp. Cell Res. 294: 392-405, 2004.
- Marinissen M-J, Chiariello M, Tanos T, BERNARD O, Narumiya S and Gutkind JS. The small GTP-binding protein RhoA regulates c-Jun by a ROCK-JNK signalling axis. Molecular Cell 13: 29-41, 2004.
- Soosairajah J, Maiti S, Sarmiere P, Moussi N, Wiggan O, Bamburg R and BERNARD O. The Interplay between LIM kinase1 and Slingshot Phosphatase Regulates the Phosphorylation of ADF/cofilin. EMBO J 24(3):473-86, 2005.
- Gorovoy M, Nie J, BERNARD O, Profirovic-Palovic J, Minshal R, and Vonyo-Yasenetskaya T. Coordination of Microtubule and actin cytoskeleton by LIM kinase 1 in human endothelial cells. J Biol Chem. 280:26533-26542, 2005.
- Tursun B, Schluter A, Peters MA, Viehweger B, Ostendorff HP, Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, BERNARD O, and Ingolf Bach. The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones Genes&Development, 19:2307, 2005.
- Karla Acevedo, Nathalie Moussi, Rong Li, Priscilla Soo and ORA BERNARD. LIM kinase 2 is widely expressed in all tissues. J. Histochemistry and Cytochemistry 54(5):487-501,2006
- Rong Li, Juliana Soosairajah, Daniel Harari, Ami Citri, John Price, Hooi Ling Ng, Craig J. Morton, Michael W. Parker, Yosef Yarden & ORA BERNARD. Hsp90 increases LIM kinase activity by promoting its homo-dimerization FASEB J, 2006 (in press).
