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Member Profiles: Group Leader: Lab Heads:
Research Scientists: |
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Laboratory Members
Dr Balasubramanian Krishnamurthy
JDRF Post Doctoral Fellow
Immunology and Diabetes Unit
St Vincent's Institute
Telephone: +61 3 9288 3513
Facsimile: +61 3 9416 2676
Email: bmurthy@svi.edu.au
Education:
| 1992 | MBBS, Bangalore Medical College, Bangalore, India |
| 1998 | MD, SN Medical College, Agra, India. |
| 2002 | DM (Endocrinology), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India |
Awards:
| 2004 | Juvenile Diabetes Research Foundation Postdoctoral Fellowship | 2009 | Juvenile Diabetes Research Foundation Career Development Award |
Scientific Involvement:
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Endocrine Society of India | |
Pediatric and Adolescent Endocrinology Chapter of Indian Academy of Pediatrics |
Research Interests:
In NOD mice, insulin and IGRP are known to be important antigens in activating CD8+ T cells that mediate destruction of insulin-producing beta cells of the pancreas. NOD mice can be protected from development of diabetes by administering one of these antigens or by genetically engineering NOD mice to over express the antigen (eg. proinsulin). We are interested in understanding how induction of protection by administration of one antigen influences immune response to other.
Publications:
- Balasubramanian K, Dabadghao P, Bhatia V, Colman PG, Gellert SA, Bharadwaj U, Agrawal S, Shah N, Bhatia E. High frequency of type 1B (idiopathic) diabetes in North Indian children with recent-onset diabetes. Diabetes Care. 2003 Sep;26(9):2697.
- Balasubramanian K, Rajeswari J, Gulab, Govil YC, Agarwal AK, Kumar A, Bhatia V. Varying role of vitamin D deficiency in the etiology of rickets in young children vs. adolescents in northern India. J Trop Pediatr. 2003 Aug;49(4):201-6
- Rajeswari J, Balasubramanian K, Bhatia V, Sharma VP, Agarwal AK. Aetiology and clinical profile of osteomalacia in adolescent girls in northern India. Natl Med J India. 2003 May-Jun;16(3):139-42.
- Bhatia E, Kordonouri O, Balasubramanian K, Rajeswari J, Landt O, Simon P, Lerch MM, Witt H. Absence of association between SPINK1 trypsin inhibitor mutations and Type 1 or 2 diabetes mellitus in India and Germany. Diabetologia. 2003 Dec;46(12):1710-1.
- Balasuramanian K and Bhatia E. Molecular mechanisms of long-term complications of diabetes. In: New vistas in type 2 diabetes (2001); Dash RJ (Ed) Vol 1, pp 91-102
- Bhatia V, Arya V, Dabadghao P, Balasubramanian K, Sharma K, Verghese N, Bhatia E. Etiology and outcome of childhood and adolescent diabetes mellitus in North India. J Pediatr Endocrinol Metab. 2004;17(7):993-9.
- Gome J, Balasubramanian K, Ward G, Jenkins A. Diabetes in the young: not always as it seems. Intern Med J. 2005 May;35(5):309.
- Balasubramanian K, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest 2006; 116(12):3258-65. This paper attracted an opinion piece in this journal. It was also mentioned in roundups in other influential journals e.g. in Nature, and it was classified as a must read by the Faculty of 1000.
- Balasubramanian K, Mariana L, Gellert SA, Colman PG, Harrison LC, Lew AM, Santamaria P, Thomas HE, Kay TWH Autoimmunity to both proinsulin and IGRP is required for diabetes in NOD8.3 TCR transgenic mice. Journal of Immunology 2008; 180:4458-4464
