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Laboratory Members
Dr. Jorg Heierhorst
Head
Molecular Genetics Unit SVIMR
St Vincent's Institute
NHMRC Senior Research Fellow
Associate Professor, Dept of Medicine SVH, The University of Melbourne
Telephone: +61 3 9288 2503
Facsimile: +61 3 9416 2676
Email: jheierhorst@svi.edu.au
ﾠ Education:
| 1992 | Medical School Graduate, University of Hamburg, Germany. |
| 1993 | Doctor of Medicine (summa cum laude), University of Hamburg, Germany |
| 1995 | Postdoctoral Training, Mount Sinai School of Medicine, New York |
Awards:
| 1987 | Friedrich-Ebert-Stiftung Scholarship (until 1992). |
| 1993 | HFSP Long-term Fellowship (until 1995). |
| 1995 | German Research Council (DFG) Fellowship (until 1997). |
| 1998 | NHMRC R.D. Wright Career Development Award (1998-2001). |
| 1999 | Australian Academy of Sciences International Travel Award. |
| 2002 | NHMRC Senior Research Fellowship (2002-2006). |
| 2007 | NHMRC Senior Research Fellowship (2007-2011). |
|
1998-date |
9 NHMRC Research Project Grants and 2 Cancer Council Victoria Grants-in-Aid as Leading/Sole Chief Investigator |
Scientific involvement (selected)
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Member, NHMRC Grant Review Panel (2006, 2007, 2008).
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Member, Council and Medical & Scientific Committee, Cancer Council of Victoria (2008 - present).
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Member, Victorian Cancer Agency Early Career Network Committee (2007-present).
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Member, Human Research Ethics Committee (Institutional Review Board), St. Vincent's Health Melbourne (2003-present).
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Organising Committee and Program Committee, XXIII International Conference on Yeast Genetics and Molecular Biology 2007.
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Organising Committee, Australian Cell Cycle Workshop, 2004, 2006 and 2008.
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Organising Committee, Australian Telomere Workshop, 2006 and 2008.
Research interests
DNA repair pathways; nuclear organization of DNA repair centers; cell cycle checkpoint responses to DNA damage; role of DNA damage response proteins in telomere maintenance; modular protein domains involved in DNA damage signalling.
Selected Publications
- Heierhorst J, Kobe B, Feil SC, Parker MW, Benian GM, Weiss KR & Kemp BE (1996).ﾠ Ca2+/S100 regulation of giant protein kinases.ﾠ Nature 380, 636-39.
- Hammet A, Pike BL, Mitchelhill KI, Teh T, Kobe B, House CM, Kemp BE & Heierhorst J (2000).ﾠ FHA domain boundaries of the Dun1p and Rad53p cell cycle checkpoint kinases.ﾠ FEBS Lett. 471, 141-146.
- Du X-J, Cole TC, Gao X-M, Tenis N, Kontgen F, Kemp BE & Heierhorst J (2002).ﾠ Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice.ﾠ Mol. Cell. Biol. 22, 2821-2829.
- Pike BL, Yongkiettrakul S, Tsai M-D & Heierhorst J (2003). Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation.ﾠ J. Biol. Chem. 278, 30421-30424.ﾠ
- Pike BL, Yongkiettrakul S, Tsai M-D & Heierhorst J (2004).ﾠ Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G2/M cell cycle progression in Saccharomyces cerevisiae.ﾠ Mol. Cell. Biol. 24, 2779-2788.
- McNees CJ, Conlan LA, Tenis N & Heierhorst J (2005).ﾠ ASCIZ regulates lesion-specific RAD51 focus formation and apoptosis after methylating DNA damage.ﾠ EMBO J. 24, 2447-2457.ﾠ
- Traven A & Heierhorst J (2005). SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA damage response proteins.ﾠ BioEssays 27, 397-407.
- Pike BL & Heierhorst J (2007).ﾠ Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.ﾠ Mol. Cell. Biol. 27, 6532-6545.ﾠ
- Hammet A, Magill C, Heierhorst J & Jackson SP (2007).ﾠ Rad9 BRCT domains interact with phosphorylated H2AX to regulate the G1 checkpoint in budding yeast.ﾠ EMBO Rep. 8, 851-857.
- Lee H, Yuan C, Hammet A, Mahajan A, Wu MR, Chen ESW, Su MI, Heierhorst J* & Tsai MD (2008). Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol. Cell 30, 767-778. (*co-corresponding author)[Featured Article, Mol. Cell online June 19-July 9, 2008; Preview, Mol. Cell 31, 1-2; Editor's Choice, Science 321, 17; Editor's Choice, Sci. Signal. 1, ec230; F1000 recommendation]
