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Member Profiles: Group Leader: Lab Heads: |
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Laboratory Members
Prof Bruce E. Kemp
Pehr Edman Fellow
Protein Chemistry & Metabolism Unit
St Vincent's Institute
Telephone: +61 3 9288 2480
Facsimile: +61 3 9416 2676
Email: bkemp@svi.edu.au
Previous Positions:
- Deputy Director of St Vincent's Institute from 1988 to 2004;
- NHMRC Fellow, 1980-84, Howard Florey Institute; 1985-88 University Melbourne, Repatriation General Hospital, Heidelberg.
Other Positions:
- Federation Fellow, CSIRO Health Sciences & Nutrition
- Professorial Associate Department Medicine, The University of Melbourne, St Vincent's Hospital
Education:
| 1970 | B Ag. Sci. (Hons), Adelaide University |
| 1975 | PhD Flinders University |
Awards:
| 1988 | Selwyn Smith Prize for Medical Research |
| 1989 | Newman Award for Excellence in AIDS Research (shared award) |
| 1989 | AIDS Trust of Australia Award |
| 1990 | Pharmacia-L.K.B. Medal and Travelling Fellowship Award |
| 1990 | The Wellcome Australia Medal for Medical Research and Technology Development |
| 1991 | The Wellcome Rapid Diagnostics Award |
| 1996 | Lemberg Medal. Australian Society for Biochemistry and Molecular Biology |
| 1996 | The Royal Society of Victoria Research Medal for 1996 for Scientific Research, Biological Sciences |
| 2000 | Fellow Australian Academy of Science |
| 2000 | Max Planck Award |
| 2002 | Fellow Royal Society UK |
| 2003 | Federation Fellow |
| 2003 | Centenary Medal (Australia) |
Scientific Involvement:
| 1981-1984, 1989-present | Lorne Protein Conference Committee |
| 1997-2003 | Board Member, Genomic Disorders Research Centre, Fitzroy, Melbourne |
| 1998-present | Scientific Advisory Board for National Serology Reference Laboratory (NSRL), NSRL Management Committee |
| 1993-2003, 1999-present | Scientific Advisory Boards, Bresagen (1993-2003) (South Australia), Mercury Therapeutics 1999-(Boston, USA) |
| Sept 1998 | Organizing committee Krebs 80 Symposium Alta Vista, Utah |
| 1999, 2000 | Gordon Research Conference "Second Messengers and protein phosphorylation", Vice Chairman 1999 Co-Chairman 2000, Kimball Union Academy Meridin. |
| 2001 | Second-messengers and phosphoproteins. 11th International meeting, Chairman Melbourne Australia. |
| 2004 | 3rd International Symposium on AMPK, Chairman, Lorne Australia |
Editorial:
| 1988-present | Cellular Signalling-founding |
| 1992-97 | Biochim Biophys Acta |
| 1994-96 | Biochemistry Journal |
| 1998-2003 | Journal Biological Chemistry |
| 2005-present | Journal of Molecular and Genetic Medicine |
Research Interests:
- Protein Chemistry & Metabolism
- protein phosphorylation
- instrasteric regulation
- peptide substrates and inhibitors
- AMP activated protein kinase
Protein Phosphorylation
How protein phosphorylation regulates protein function, and how AMP activated protein kinase regulates metabolic and gene transcriptional responses to exercise and metabolic stress. Drug design to increase exercise capacity and reduce age onset diseases. The fat/vanity pill, exercise in a pill.
Obesity, diabetes endurance performance, drug design
ISI under Highly Cited in Biology & Biochemistry (1981-1999) Medline listings 251, Papers in Nature, 5 and Science 7. The first and seventh most cited papers in Australian Medical Research (Analysis of the impact of Australian biomedical research by Bourke and Butler ("The Research Enterprise: Mapping Australia's basic research in the medical and health sciences" Medical Journal of Australia 167: 610-3, 1997)
Publications:
- Kemp, B.E., Benjamini, E. and Krebs, E.G. Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA, 73, 1038-1042, 1976.
- Kemp, B.E., Graves, D.J., Benjamini, E. and Krebs, E.G. Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase. J. Biol. Chem., 252, 4888-4894, 1977.
- Kemp, B.E., Pearson, R.B., Guerriero Jr., V., Bagchi, I.C. and Means, A.R. The calmodulin-binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. J. Biol. Chem., 262, 2542-2548, 1987.
- House, C. and Kemp, B.E. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science, 238, 1726-1728, 1987
- Kemp, B.E., Moseley, J.M., Rodda, C.P., Ebeling, P.R., Wettenhall, R.E.H., Stapleton, D., Diefenbach-Jagger, H., Ure, F., Michelangeli, V.P., Simmons, H.A., Raisz, L.G. and Martin, T.J. Parathyroid hormone-related protein of humoral hypercalcemia of malignancy: biologically active synthetic fragments. Science, 238, 1568-1570, 1987
- Pearson, R.B., Wettenhall, R.E.H., Means, A.R., Hartshorne, D.J. and Kemp, B.E. Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. Science, 241, 970-973, 1988.
- Kemp, B.E. and Pearson, R.B. Protein kinase recognition sequence motifs. Trends Biochem. Sci., 15, 342-346, 1990.
- Hu, S-H., Parker, M.W., Lei, J.Y., Wilce, M.C.J., Benian, G.M. and Kemp, B.E. Insights into autoregulation from the crystal structure of twitchin kinase. Nature, 369, 581-584, 1994.
- Mitchelhill, K.I., Stapleton, D., Gao, G., House, C., Michell, B., Katsis, F., Witters, L.A. and Kemp, B.E. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J. Biol. Chem., 269, 2361-2364, 1994.
- Chen, Z-P, Mitchelhill, K.I., Michell, B.J., Stapleton, D., Rodriguez-Crespo, I. Witters, L.A., Power, D.A., Oritz de Montellano, P.R. and Kemp, B.E. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett. 443, 285-289, 1999
- Chen, Z-P, T.J. Stephens, S. Murthy, B. J. Canny, M. Hargreaves, L.A. Witters, B.E. Kemp and G.K. McConell. Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes, 52, 2205-2212, 2003
- Adams, J., Chen, Z-P., van Denderen, B.J.W., Morton, C.J., Parker, M.W., Witters, L.W., Stapleton, D. and Kemp, B.E. Intrasteric control of AMPK via the g1 subunit AMP allosteric regulatory site, Protein Science, 13, 155-65, 2004
