Bone Cell Biology and Disease - Research Units - Bone Cell Biology and Disease - Research themes
Communication between osteoblasts, osteocytes and osteoclasts
This project seeks to identify coupling factors, released by the osteoclast, that influence osteoblast and osteocyte activity, and identify their contributions to the anabolic effect of PTH and estrogen-deficiency-induced bone loss.
Staff: Ling Yeong Chia, Nicole Walsh, Sueli Pompolo
Ephrin signalling in osteoblasts
This project seeks to identify the contributions of Ephrin B2 : Eph B4 signalling in bone formation and to the effects of PTH on bone
Staff: Blessing Crimeen-Irwin, Farzin Takyar, Sueli Pompolo, Ingrid Poulton
The IL-6 / gp130 family of cytokines and bone
Local factors that signal through the gp130 receptor play critical roles in a number of diseases. Our group has identified a range of these family members that contribute to normal bone physiology, including cardiotrophin-1, IL-11, oncostatin M, and ciliary neurotrophic factor. This project seeks to understand these factors work within bone, and their importance in normal bone physiology.
Staff: Emma Walker, Narelle McGregor, Ingrid Poulton, Holly Brennan
Osteoarthritis and Rheumatoid Arthritis
This project seeks to understand the contributions of osteoblasts and osteoclasts to the joint destruction and generalised osteoporosis associated with a range of arthritic conditions including osteoarthritis, rheumatoid arthritis and reactive arthritis.
Staff: Nicole Walsh, Evange Romas, Brett Tonkin
Osteoblast commitment and osteosarcoma (joint with Carl Walkley, Stem Cell Regulation Unit)
This project seeks to understand the contributions of epigenetic regulation, ephrin and PTH signalling in normal osteoblast differentiation and in osteosarcoma.
Staff: Emma Baker, Julie Quach, Pat Ho, Pece Kokovski