Bone Cell Biology and Disease - Senior Research Staff - A/Prof Natalie A Sims

A/Prof Natalie A Sims

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Associate Director
NHMRC Senior Research Fellow
Co-head Bone Cell Biology and Disease Unit
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Education and Professional Experience

1991           BSc (Hons) The University of Adelaide, South Australia
1995           PhD The University of Adelaide, South Australia

Achievements

2010            Fuller-Albright Award, American Society of Bone and Mineral Research
2009            Board of Directors, International Bone and Mineral Society
2006            Editorial Board, Bone
2003            International Bone and Mineral Society/BONE Best Basic Science Paper Award
1999            Young Investigator Award, American Society of Bone and Mineral Research

Research Interests

Research goal: to identify new pathways for treatment of bone disease by studying intercellular communication within the bone microenvironment, particularly the communication between osteoblasts (bone forming cells) and osteoclasts (bone resorbing cells).
Approaches used include histomorphometric and ex vivo cell culture analyses of knockout animals and animal models of destructive bone diseases, with particular emphasis on diseases of bone remodeling including osteoporosis as well as work on rheumatology and osteoarthritis.

Selected Publications

  1. Walker, E.C., McGregor, N.E., Poulton, I.J., Solano, M., Pompolo, S., Fernandes, T.J., Constable, M. J., Nicholson, G.C., Zhang, J.G., Nicola, N.A., Gillespie, M.T., Martin, T. J., & Sims, N.A. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. Journal of Clinical Investigation. J Clin Invest. 2010 Feb 1;120(2):582-92. (IF:16.559)
  2. Walker, E.C., McGregor, N.E., Poulton, I.J., Pompolo, S., Allan, E.A., Quinn, J.M.W., Gillespie, M.T., Martin, T.J., & Sims, N.A. Cardiotrophin-1 is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling. Journal of Bone and Mineral Research. 2008 23(12):2025-2032 (IF: 6.443; 13 citations)
  3. Allan, E.H., K.D. Häusler, T. Wei, J. H. Gooi, J.M. Quinn, B. Crimeen-Irwin, N.A. Sims, M.T. Gillespie, J E Onyia, T.J. Martin. EphrinB2 Regulation by Parathyroid Hormone (PTH) and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts.  J Bone Miner Res. 23(8):1170-81. 2008 (IF:6.443; 15 citations)
  4. Martin, T.J., Sims, N.A. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends in Molecular Medicine. 11:76-81, 2005. (IF: 9.621; 116 citations)
  5. Sims, N.A., Green, J.R., Glatt, M., Schlict, S., Martin, T.J., Gillespie, M.T., Martin, T.J., Romas, E. (2004) Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis. Arthritis and Rheumatism. 50, 2338–2346. (IF: 6.787; 35 citations)
  6. Sims, N.A., Jenkins, B.J., Quinn, J.M.W., Glatt, M., Gillespie, M.T., Ernst, M., Martin, T.J. gp130 regulates bone turnover and bone size by distinct downstream signaling pathways Journal of Clinical Investigation 113, 379-389; 2004. (IF: 16.559; 47 citations).
  7. Martin TJ, Gooi JH, Sims NA. Molecular mechanisms in coupling of bone formation to  resorption. Critical Reviews in Eukaryotic Gene Regulation. 19: 61-72, 2009.
  8. Askmyr M, Sims NA, Martin TJ, Purton LE. What is the true nature of the osteoblastic hematopoietic stem cell phenotype? Trends Endocrinol Metab 20: 303-309, 2009
  9. Sims, N.A., Walsh, N.C. gp130 cytokines and bone remodeling in health and disease. BMB Reports. 2010 Aug;43(8):513-2.