Cell Cycle and Cancer - Senior Research Staff - Dr Boris Sarcevic

Dr Boris Sarcevic

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Unit Head
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Education and Professional Experience

B.Sc (Hons)
PhD
Post-doc Howard Hughes Medical Institute, Denver CO, USA

Achievements

US Army Breast Cancer Invitational Travel Award

Research Interests

In higher eukaryotes, controlled cell proliferation and differentiation is required for normal growth and development. Deregulation of cell growth pathways leading to unrestrained cell division is a primary characteristic of cancerous cells. Therefore, defining the causes of increased cellular division is fundamental to understanding carcinogenesis. Our group is interested in understanding the molecular mechanisms of cell division and how deregulation of these pathways contributes to the development of human cancer. Our research ultimately aims to develop new approaches for cancer therapy.

Selected Publications

  1. Martin Sadowski, Randy Suryadinata, Xianning Lai, Jorg Heierhorst and Boris Sarcevic (2010) Molecular basis for lysine specificity in the yeast ubiquitin conjugating enzyme Cdc34 Mol. Cell. Biol., 30, 2316-2329
  2. Martin Sadowski and Boris Sarcevic (2010) Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino aciod residues proximal to the lysine Cell Division 5, 19
  3. Martin Sadowski, Rohan Baker, Amanda Mawson and Boris Sarcevic (2007) Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression Biochem. J. 405, 569-581
  4. Amanda Mawson, Angela Lai, Jason S. Carroll, C. Marcelo Sergio, Christopher J. Mitchell and Boris Sarcevic (2005) Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1 Molec. Cell. Endocrinol 229, 161-173
  5. Megan Fabbro, Bin-Bing Zhou, Mikiko Takahashi, Boris Sarcevic, Preeti Lal, Mark E. Graham, Brian G. Gabrielli, Phillip J. Robinson, Erich A. Nigg, Yoshitaka Ono and Kum Kum Khanna (2005) Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis Dev. Cell 9, 477-488
  6. Timothy C.Tan, Valentina A. Valova, Chandsra S. Malladi, Mark E. Graham, Leise A. Berven, Orla J. Jupp, Gurdip Hansra, Sonya J. McClure, Boris Sarcevic, Ross A. Boadle, Martin R. Larsen, Michael A.Cousin and Phillip J. Robinson (2003) Cdk5 is essential for synaptic vesicle endocytosis Nat. Cell Biol. 5, 701-710
  7. Boris Sarcevic, Amanda Mawson, Rohan T. Baker and Robert L. Sutherland (2002) Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation EMBO J. 21, 2009-2018
  8. Boris Sarcevic, Richard Lilischkis and Robert L. Sutherland (1997) Differential Phosphorylation of T-47D Human Breast Cancer Cell Substrates by D1-, D3-, E- and A-, Cyclin/CDK Complexes. J. Biol. Chem. 272, 33327-33337
  9. Boris Sarcevic, Eleanor Erikson and James L. Maller. (1993) Purification and Characterisation of a Mitogen-activated Protein Kinase Tyrosine Phosphatase from Xenopus Eggs. J. Biol. Chem. 268, 25075-25083
  10. Olivier Haccard, Boris Sarcevic, Andrea Lewellyn, Rebecca Hartley, Linda Roy, Tetsuro Izumi, Eleanor Erikson and James L. Maller. (1993) Induction of Metaphase Arrest in Cleaving Xenopus Embryos by MAP Kinase. Science 262, 1262-1265