St Vincent's Institute

• Research units

• Structural Biology
  • Research Themes
  • Honours and PhD Projects
  • Staff
• Protein Chemistry and Metabolism
• Molecular Cardiology
• Immunology and Diabetes
• Bone Cell Biology and Disease
• Stem Cell Regulation
• Haematology and Leukaemia
• Molecular Genetics
• Cell Cycle and Cancer
• Cytoskeleton and Cancer
• Pharmacogenomics
• Invasion and Metastasis
• NRL
• Genome Stability

Dr Craig Morton

Principal Associate
Principal Research Scientist, Biota
Senior Lecturer, Department of Biochemistry and Molecular Biology, Monash University

Education and Professional Experience

BSc (Hons)
PhD (Melb)

Achievements

.

Research Interests

Structural biology and drug design, particularly the interface between experimental structural techniques (crystallography, NMR, etc.) and modelling techniques (homology models, in silico screening etc.).

Selected Publications

1. W.H. Ang, L.J. Parker, A. De Luca, L. Juillerat-Jeanneret, C.J. MORTON, M. Lo Bello, M.W. Parker, P.J. Dyson. Rational design of an organometallic glutathione transferase inhibitor. Angew Chem Int Ed Engl. (2009) 48:3854-3857.
2. J.M. Fletcher, C.J. MORTON, R.A. Zwar, S.S. Murray, P.D. O'Leary, R.A. Hughes. Design of a conformationally-defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor. J Biol Chem. (2008) 283:33375-33383.
3. A.L. Albiston, C.J. MORTON, H.-L. Ng, V. Pham, H.R. Yeatman, S. Ye, R.N. Fernando, D. De Bundel, D.B. Ascher, F.A. Mendelsohn, M.W. Parker, S.Y. Chai. Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J. (2008) 22:4209-4217.
4. V.A. Avlani, K.J. Gregory, C.J. MORTON, M.W. Parker, P.M. Sexton, A. Christopoulos. Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands. J Biol Chem. (2007) 282:25677-86.
5. R. Li, J. Soosairajah, D. Harari, A. Citri, J. Price, H.-L. Ng, C.J. MORTON, M.W. Parker, Y. Yarden, O. Bernard. Hsp90 increases LIM kinase activity by promoting its homo-dimerization. FASEB J. (2006) 20:1221-1223
6. G.M. Scott, H.-L. Ng, C.J. MORTON, M.W. Parker, W.D. Rawlinson.  Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus. J Gen Virol. (2005) 86:2141-51.
7. V. Pham, M. Dong, J.D. Wade, L.J. Miller, C.J. MORTON, H.-L. Ng, M.W. Parker, P.M. Sexton.  Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling. J Biol Chem. (2005) 280:28610-22.
8. C.J. MORTON, R. Cameron, L.J. Lawrence, B. Lin, M. Lowe, A. Luttick, A. Mason, J. McKimm-Breschkin, M.W. Parker, J. Ryan, M. Smout, J. Sullivan, S.P. Tucker, P.R. Young. Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay. Virology. (2003) 311:275-88.
9. Y. Tsitrin, C.J. MORTON, C. el-Bez, P. Paumard, M.C. Velluz, M. Adrian, J. Dubochet, M.W. Parker, S. Lanzavecchia, F.G. van der Goot. Conversion of a transmembrane to a water-soluble protein complex by a single point mutation. Nat Struct Biol. (2002) 9:729-33.
10. D. Kohda, C.J. MORTON, A.A. Parkar, H. Hatanaka, F.M. Inagaki, I.D. Campbell and A.J. Day. The three dimensional structure of a hyaluronan binding Link module from human TSG-6: homology with the C-type lectin domain. Cell (1996) 86: 767-775