St Vincent's Institute

• Research units

• Structural Biology
  • Research Themes
  • Honours and PhD Projects
  • Staff
• Protein Chemistry and Metabolism
• Molecular Cardiology
• Immunology and Diabetes
• Bone Cell Biology and Disease
• Stem Cell Regulation
• Haematology and Leukaemia
• Molecular Genetics
• Cell Cycle and Cancer
• Cytoskeleton and Cancer
• Pharmacogenomics
• Invasion and Metastasis
• NRL
• Genome Stability

Dr Michael Gorman

Senior Research Officer 

Education and Professional Experience

1985–89     Bsc (Hons) Biochemistry, John Moores University, Liverpool, UK
1993–98     PhD, Imperial Cancer Research Fund, London,UK
2001-06      Post-doctoral Fellow, Walter and Eliza Hall Institute, Melbourne, Australia
2006-          Senior Research Officer, St. Vincents Institute, Australia

Achievements

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Research Interests

I am a member of the Cancer Therapeutics CRC Pty Ltd (CTx) which is a pharmaceutical discovery and development company. Its purpose is to develop Australia's leading cancer discoveries into new cancer drugs. It has an A$148 million investment over the next seven years including A$38 million from the Australian Government's Cooperative Research Centres (CRC) Programme and about A$110 million in investments from CTx's partners, one of which is St Vincent's Institute.

Selected Publications

1. *Webb, C.T., *Gorman, M.A., Lazarou, M., Ryan, M.T., and Gulbis, J.M., Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Mol Cell, 2006. 21(1): p. 123-33.
2. *Cromer, B.A., *Gorman, M.A., *Hansen, G., Adams, J.J., Coggan, M., Littler, D.R., Brown, L.J., Mazzanti, M., Breit, S.N., Curmi, P.M.G., Dulhunty, A.F., Board, P.G. & Parker, M.W. Structure of the Janus protein human CLIC2. J. Mol. Biol., 2007 p. 374, 719-31.
3. Feil, S.C., Polekhina, G., Gorman, M.A. and Parker, M.W.  In Proteins: Membrane Binding and Pore Formation, eds Anderluh, G. and Lakey, J. Springer press (2010) p. 1 -13.
4. Gorman, M.A., Morera, S., Rothwell, D.G., de La Fortelle, E., Mol, C.D., Tainer, J.A., Hickson, I.D., and Freemont, P.S., The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites. EMBO J, 1997. 16(21): p. 6548-58.
5. Hickson,I.D., Gorman, M.A. and Freemont, P.S. Structure and functions of the Major Human AP Endonuclease APE1 (2001) pp 87-0. In DNA Damage and Repair Vol III: Advances form Phage to Humans, Humana Press.
6. Sibarani, N.E., Gorman, M.A., Dogovski, C., Parker, M.W. & Perugini, M.A. Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae.  2010. Acta Cryst., Sect F. 66, p. 32-36.
7. Dommaraju, S., Gorman, M.A., Dogovski, C., Pearce, F.G., Gerrard, J.A., Dobson, R.C.J., Parker, M.W. & Perugini, M.A. Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus. 2010. Acta Cryst., Sect F. 66, p. 57-60.
8. Zhang, X., Shaw, A., Bates, P.A., Newman, R.H., Gowen, B., Orlova, E., Gorman, M.A., Kondo, H., Dokurno, P., Lally, J., Leonard, G., Meyer, H., van Heel, M., and Freemont, P.S., Structure of the AAA ATPase p97. Mol Cell, 2000. 6(6): p. 1473-84.