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Bioinformatician

The Research Group 

The Bioinformatics and Cellular Genomics group at St Vincent’s Institute of Medical Research SVI (St Vincent’s Institute) seeks an individual to join our diverse research team. We are broadly interested in all the ways in which computational approaches can drive biological discovery. We develop methods and software for the analysis of large-scale biomedical data from imaging and sequencing technologies, particularly single-cell data. We work closely with a wide range of collaborators to contribute computational expertise to studies motivated by specific biologically focused questions. 

The Role 

This unique opportunity emphasizes research bioinformatics. The applicant will have responsibility for their own bioinformatics research projects and for enhancing the capabilities of the Bioinformatics and Cellular Genomics (BioCellGen) team. The applicant will work independently or under immediate technical direction. The successful applicant will work closely with the BioCellGen team, developing strong interactions between team members and computational and wet-lab colleagues. The applicant will lead technical development and maintenance of bioinformatics and computing resources and contribute to bioinformatics training of colleagues.    

Key Duties 

This role exists to participate in bioinformatics research at St Vincent’s Institute, applying computational approaches to drive biological discovery through sophisticated analysis of large and complex biological/biomedical datasets, developing new methods and software for analysing such data, and providing technical expertise in scientific computing to support the work of the BioCellGen team. 

Selection Criteria 

The successful candidate for this position will, as a minimum, hold a relevant Bachelors Degree with two years of experience in bioinformatics, computer science, statistics, biostatistics, machine learning, or related disciplines. A Masters or higher level qualification is preferred.  

Experience with data analysis and/or software development in relevant programming languages, for example R, Python, C / C++, Julia, Rust is essential as is experience with software development best practices appropriate for small teams, for instance use of version control, unit tests, agile project management, and creation of end-user documentation. 

You will also be familiar with statistical concepts and methods. 

Ideally you will also bring; 

  • Experience with high-volume genetic/genomic data, such as from sequence analysis pipelines, and/or experience with high-resolution image data, such as from radiology, spatial transcriptomics, or microscopy technologies.   
  • Familiarity with bioinformatic workflows, especially related to single-cell genomics. 
  • Familiarity with parallel and cluster-based processing and other high-performance computing environments. 
  • Experience and enthusiasm for diverse programming languages and paradigms, and 
  • Familiarity with R's S4 object-oriented system, and with core Bioconductor software packages 

To be considered you will be required to provide evidence that you have permanent working rights in Australia or hold a relevant working visa to work full-time hours, as well as being fully vaccinated for COVID-19.  

Position Description attached 

Salary will be determined based on the applicant’s qualifications and prior relevant experience. Other benefits include generous FBT exempt salary packaging of up to $15,900 pa. 

Further information:   
Dr. Davis McCarthy 
Email: [email protected]  

To apply: All applications should be addressed to Dr. Davis McCarthy. Applications must include a covering letter including: (i) a brief outline of the applicant’s training and experience, (ii) an outline of their skills and experience in relation to the selection criteria listed in the position description. In addition, please include a current CV. Applications which do not follow these instructions will not be considered further. Please apply via SEEK - https://www.seek.com.au/job/59236536

We will commence interviewing candidates of interest as they apply and therefore, we may fill this position before the indicative SEEK closing date. 

Closing Date: Wednesday 30th November 2022

Position Description
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Postdoctoral Researcher - Human Immunology

The Role

We are seeking a self-motivated Postdoctoral Researcher to join the Human T-cell Laboratory team headed by A/Prof Stuart Mannering. This role will contribute to our body of knowledge on the autoimmune basis of type 1 diabetes by leading research projects and undertaking a range of experiments analysing the specificity and function of human immune cells in type 1 diabetes.

Key Duties

The key responsibilities for this role are to drive the experimental research program within the Human T-cell laboratory

  • Undertake experiments that progress research projects within the context of the laboratory’s research goals.
  • Undertake experimental research using current and emerging methods
  • Analyse the results of experiments and keep records of experimental results.
  • Develop new experimental approaches and troubleshoot existing methodologies
  • Contribute to the preparation of paper manuscripts and grant applications
  • Write abstracts and present at relevant national and international conferences and meetings
  • Supervise and mentor the group’s junior staff and students
  •  Assist with the management and collection of human tissue samples.
  • Provide training and assistance with experiments to other members of the laboratory, as well as external collaborators as required.
  • Support the work of students in the laboratory.
  • Contribute, from time to time, to other experiments within the Unit.
  • Present data at lab meetings.
  • Maintain knowledge of the current literature in the field and methodologies.
  • Meet regularly with A/Prof Mannering to discuss results and plan future work
  • Provide input into the lab’s research direction
  • As required, oversee the work of casual laboratory staff
  • Other laboratory tasks as required.

Selection Criteria

To be successful in obtaining this position you will have:

  • A PhD in immunology, or in a very similar biomedical field with post graduate experience in immunology.
  • Demonstrated high level technical skills in biomedical research.

Highly Desirable

  • Expertise in protein expression and purification.
  • Knowledge of, and experience in, antibody expression and B-cell biology.
  • Experience with single-cell sequencing
  • Experience in the functional analysis of T cells.

To be considered you shall be required to provide evidence you have permanent working rights in Australia or hold a relevant working visa to work full-time hours, as well as being fully vaccinated for COVID-19. 

Salary

$89,606 to $96,187 per annum plus 10.5% superannuation.

Salary will be determined based on the applicant’s qualifications and prior relevant experience. Other benefits include generous FBT exempt salary packaging of up to $15,900 pa.

Further information:  
A/Prof Stuart Mannering
Email: [email protected]

Applications via Seek Only: https://www.seek.com.au/job/59142934

To apply: All applications should be addressed to A/Prof Stuart Mannering. Applications must include a covering letter including: (i) a brief outline of the applicant’s training and experience, (ii) an outline of their skills and experience in relation to the six selection criteria listed above. In addition, please include a current CV. Applications which do not follow these instructions will not be considered further.

Closing Date:  COB 7 December 2022

We will commence interviewing candidates of interest as they apply and therefore, we may fill this position before the indicative closing date.

Closing Date: Wednesday 7th December 2022

Position Description
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Post Doctoral Research Officer - Bioinformatics

Facility

St Vincent’s Institute (SVI) is an internationally recognized independent research organization, based on the St Vincent’s Hospital Campus on the edge of Melbourne’s CBD. The Institute has a dedicated team of over 250 staff and students, who are committed to improving the health and life-expectancy of Australians. We focus on common diseases that represent major health issues for Australians today, including diabetes, bone diseases, cancer, cardiovascular disease, obesity and Alzheimer’s disease. With an exceptional pool of talented researchers and a growing number of state-of-the-art facilities, we are enthusiastic about the future. 

Laboratory & Research Focus:

The DNA Repair and Recombination Laboratory is an established research group at SVI, focused on understanding the genetic control of DNA repair and recombination and the role that these processes play in inheritance and oncofertility. You will bring your skills as a bioinformatician and will work closely with wetlab researchers in the same team for all experimental stages from planning through to data analysis. You will be a self-motivated researcher with a PhD, first author publications and strengths in bioinformatics, genomics and/or digital image analysis, statistics, computation, and reproducible analyses. The role will be a mixture of semi-autonomous research and providing support as required to the wetlab part of the team. You may have the opportunity to develop your own research projects by negotiation.

To address our biological questions, we use a number of tools that produce large datasets which includes: histological and immunofluorescence microscopy, bulk high-throughput sequencing of genomic DNA, single-cell sequencing of genomic DNA, whole animal phenotyping from pedigrees, and other cell-based phenotypic datasets. The team is specifically interested in performing discovery research and identifying and characterising phenotypes which in turn improves our understanding of our biological interests.

Having a diverse workforce that represents the global and Australian community is very important to our team and we actively encourage applications from Aboriginal and Torres Strait Islanders, people with disabilities, from culturally and linguistically diverse backgrounds, LGBTQIA+ people, and all genders.

NHMRC-funded Position

We are seeking a self-motivated and passionate bioinformatics postdoc to join the DNA Repair and Recombination Laboratory team headed by Associate Professor Wayne Crismani. This role involves:

  • Performing exploratory data analysis in the areas of genetics and image analysis 
  • Exploratory data analyses should produce hypotheses which can be tested
  • Advising wet lab scientists on data practices 
  • Wrangling high throughput screening datasets 
  • Package development where appropriate


Essential selection criteria:

  • Enthusiasm for science is a must
  • PhD in a computational discipline and demonstrable experience bioinformatics, genomics and genetics.
  • Proficiency in computer programming and scripting in one or more of the following languages: R, Python, C++, Go, Nim, Rust, Java, Perl, SQL. 

Salary: commensurate with experience ranging from $89,606 to $96,187 per annum, plus 10.5% superannuation and generous $15,900 FBT exempt salary packaging. 

Position Descriptions: https://www.svi.edu.au/careers_students/careers/current_vacancies

For a confidential discussion about the role:  [email protected]

Applications should be directed to Wayne Crismani by email - [email protected]

To apply, please include the following as PDFs:

  • CV (one page max) – Please limit publications to your top three with a brief descriptor of your contribution to these works. 
  • Cover letter (one page max) – Please explain why you will be a good fit for this role.

(Please note we will commence interviewing candidates of interest as they apply so if you are interested in this role please submit an application as soon as possible)

Closing Date: Wednesday 30th November 2022

Position Description
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Biological Logistics Officer

Organisational Context

The National Reference Laboratory (NRL) operates as a division of St Vincent’s Institute whose mission is to improve the health of the community by prevention, detection, or better treatment of common diseases. NRL was established as part of the Australian Government’s HIV and AIDS strategy. Contracted by the Dept Health and licensed by the Therapeutic Goods Administration (TGA), NRL undertakes scientific activities that support the accurate diagnosis and management of human communicable diseases, including HIV, COVID-19, HCV and HTLV. NRL provides unique and specialised services, including pre- and post-market evaluations of serology test kits, quality assurance programmes, specialised testing services, consultation, education and training for laboratories in Australia and worldwide.

The role

We have an exciting opportunity for a full time Biological Logistics Officer to support NRL’s logistics function by ensuring efficient and timely logistic service for NRL domestic and international customers in line with the organisation’s strategic objectives. The Biological Logistics Officer plays a vital role to support the Logistics Co-Ordinator in delivering scheduled shipments of both External Quality Assurance (EQAS) samples and Ad Hoc materials on behalf of all NRL business functions. Key responsibilities of the Biological Logistics Officer will be to supervise and perform ‘pick and pack’ of biological materials in line with relevant IATA Dangerous Goods Regulations while adhering to correct temperature requirements, assist with the generation of manifests, relevant export and customs documentation and liaise with couriers for scheduled dispatch of shipments and tracking deliveries. The Biological Logistics Officer will communicate with customers and appropriate stakeholders to inform of delays or the rescheduling of shipments.

Skills and experience required

You will have significant experience in the handling of biological goods within an accredited biological laboratory environment. You will have experience of performing and supervising the ‘pick and pack’ of biological goods and an understanding of import/export processes. Experienced in the shipping of biological materials and a relevant IATA Dangerous Goods certification is highly desirable. You will adhere to and contribute to maintaining NRL’s Quality Management System and comply with standard operating procedures and policies. You will be customer focused, highly organized with demonstrated attention to detail, advanced analytical and problem-solving skills, and an individual who prides themselves on a high level of accuracy in their work.

To be considered you will be required to provide evidence that you have permanent working rights in Australia or hold a relevant working visa to work full-time hours, as well as being fully vaccinated for COVID-19

Salary: commensurate with qualifications and experience, ranging from $67,000 to $77,000 per annum, plus:

  • $15,900 FBT exempt salary packaging and 
  • 10.5% superannuation. 

Position Description and Selection Criteria  https://www.svi.edu.au/careers_students/careers/current_vacancies 

Further information:  Jenny Catimel– [email protected]               

Applications via Seek https://www.seek.com.au/job/59288019

Please click on the apply now button, to be addressed to Jenny Catimel and must include:

  • Current CV: and 
  • Cover letter addressing the Selection criteria found on the St Vincent's Institute website

Closing Date: COB Wednesday, 21 December 2022

We will commence interviewing candidates of interest as they apply and therefore, we may fill this position before the indicative closing date.

Closing Date: Wednesday 21st December 2022

Position Description
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