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Student Research Projects

How are lysosomal processes involved in bone mineralisation?

Disease Focus: Osteoporosis

Project Type: Honours
Supervisor(s): Prof Natalie Sims

What controls the development of strong cortical bone?

Disease Focus: Osteoporosis

Project Type: PhD/Masters/Honours
Supervisor(s): Prof Natalie Sims

Understanding the function of the DNA helicase RECQL4 in normal and cancer biology

Disease Focus: Rare diseases

Project Type: Masters/PhD
Supervisor(s): Dr Monique Smeets & Prof Carl Walkley

Identifying IL-27 dependent pathogenic mechanisms in Type 1 Diabetes

Disease Focus: Type 1 diabetes

Project Type: Masters/Honours
Supervisor(s): Dr Andrew Sutherland

Mechanisms of Regulatory T cell action in Type 1 Diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Andrew Sutherland

Complex liver organoids

Disease Focus:

Project Type: Honours
Supervisor(s): A/Prof Geraldine Mitchell & Dr Kiryu Yap, RA and PhD student

Mapping the cellular network that regulates immunogenicity of self nucleic acids

Disease Focus: Rare diseases

Project Type: Masters/PhD
Supervisor(s): Dr Jacki Heraud-Farlow & Prof Carl Walkley

Activation of nucleolar-specific DNA damage response as a therapeutic strategy for ovarian cancer

Disease Focus: Cancer

Project Type: Masters/Honours
Supervisor(s): A/Prof Elaine Sanij

Regulation of blood cell production by endothelial cell-derived retinoic acid receptor gamma

Disease Focus: Cancer

Project Type: Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin

Identifying better therapies for patients with myelodysplastic syndromes

Disease Focus: Cancer

Project Type: PhD/Honours
Supervisor(s): Prof Louise Purton

The impact of cancer therapies on the bone marrow microenvironment

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin

How do bone marrow microenvironments regulate B lymphocyte production?

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin

Developing a new drug with anticancer and cardioprotective dual therapeutic effects

Disease Focus: Cancer, Heart disease

Project Type: Masters/PhD
Supervisor(s): Dr Shiang (Max) Lim

Modelling cardiovascular diseases using human cardiac organoids

Disease Focus: Heart disease, Type 2 diabetes

Project Type: Masters/PhD
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees

How does the periosteum control bone width?

Disease Focus: Osteoporosis

Project Type: PhD/Masters/Honours
Supervisor(s): Prof Natalie Sims & Dr Natalie Wee

Benchmarking of data reconstruction methods in single-cell genomics

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

Deep learning for clinical image data

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

New methods to study tumour heterogeneity with single-cell genomic data

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

Statistical methods and software for population-scale single-cell genetics

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

Investigating a novel mechanism for improving beta-cell function in type 2 diabetes

Disease Focus: Type 2 diabetes

Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh

The role of AMP-activated kinase in suppressing atherosclerosis

Disease Focus: Heart disease

Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh

Structure-based drug design of selective Drp1 inhibitors

Disease Focus: Cancer, Neurodegeneration, Heart disease

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Christopher Langendorf

Amino acid transport: a new target for regulating immune cell function and preventing type 1 diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Tom Brodnicki & Prof Helen Thomas

Cancer drug discovery by inhibition of a DNA repair pathway with Crispr/Cas9 gene editing and biochemistry

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Wayne Crismani

Machine learning of evolutionary forces within families using single-cell sequencing

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Wayne Crismani & Dr Davis McCarthy

What are the functional properties of human CD4+ T cells, from people with type 1 diabetes, that respond to proinsulin C-peptide?

Disease Focus: Type 1 diabetes

Project Type: PhD
Supervisor(s): A/Prof Stuart Mannering

What antigens/epitopes are recognized by islet-infiltrating CD8+ T cells in people with type 1 diabetes?

Disease Focus: Type 1 diabetes

Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering

Using the JAK1/JAK2 inhibitor baricitinib to treat new-onset type 1 diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD/Honours
Supervisor(s): Prof Helen Thomas

Understanding the functions of IL-17 family receptors in type 1 diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Andrew Sutherland

The cellular fuel gauge: Novel mechanisms of metabolic control

Disease Focus: Type 2 diabetes

Project Type: PhD/Honours
Supervisor(s): A/Prof Jonathan Oakhill & Dr John W Scott

Structural biology of proteins involved in neurodegenerative disorders and mental illness

Disease Focus: Neurodegeneration

Project Type: PhD/Honours
Supervisor(s): Prof Michael Parker & Dr Jonathan Gooi

Investigating cardiovascular disease in Friedreich’s ataxia using human induced pluripotent stem cells

Disease Focus: Rare diseases, Heart disease

Project Type: Masters/PhD
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees

How to detect a T cell’s response to autoantigen?

Disease Focus: Type 1 diabetes

Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering

Factors that determine islet antigen-specific T-cell expansion before the onset of type 1 diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD
Supervisor(s): Prof Helen Thomas & Dr Bala Krishnamurthy

Drug development for metabolic diseases

Disease Focus: Type 2 diabetes, Cancer, Heart disease

Project Type: PhD/Honours
Supervisor(s): A/Prof Jonathan Oakhill & Prof Bruce E. Kemp