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Student Research Projects
Regulation of blood cell production by endothelial cell-derived retinoic acid receptor gamma
Disease Focus: Cancer
Project Type: Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin
Identifying better therapies for patients with myelodysplastic syndromes
Disease Focus: Cancer
Project Type: PhD/Honours
Supervisor(s): Prof Louise Purton
The impact of cancer therapies on the bone marrow microenvironment
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin
How do bone marrow microenvironments regulate B lymphocyte production?
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin
Developing a new drug with anticancer and cardioprotective dual therapeutic effects
Disease Focus: Cancer, Heart disease
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Shiang (Max) Lim
Modelling cardiovascular diseases using human cardiac organoids
Disease Focus: Heart disease, Type 2 diabetes
Project Type: Masters/PhD
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees
A therapeutic strategy for killing cancer cells by DNA repair inhibition
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans
How does the periosteum control bone width?
Disease Focus: Osteoporosis
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Natalie Sims & Dr Natalie Wee
The role of RNA editing enzyme ADAR1 in liver homeostasis and metabolism
Disease Focus: Rare diseases
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Jacki Heraud-Farlow & Prof Carl Walkley
Novel genetic interactions with the double-stranded RNA-induced autoimmunity pathways
Disease Focus: Rare diseases
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Carl Walkley & Dr Jacki Heraud-Farlow
Benchmarking of data reconstruction methods in single-cell genomics
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Deep learning for clinical image data
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
New methods to study tumour heterogeneity with single-cell genomic data
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Statistical methods and software for population-scale single-cell genetics
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Investigating a novel mechanism for improving beta-cell function in type 2 diabetes
Disease Focus: Type 2 diabetes
Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh
The role of AMP-activated kinase in suppressing atherosclerosis
Disease Focus: Heart disease
Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh
Structure-based drug design of selective Drp1 inhibitors
Disease Focus: Cancer, Neurodegeneration, Heart disease
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Christopher Langendorf
Function and structure of the breast cancer predisposition gene BRCA1
Disease Focus: Cancer
Project Type: PhD/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Rohan Bythell-Douglas
The role of RecQL4 gene in cancer predisposition
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans & Prof Carl Walkley
Improved gene editing by CRISPR/Cas9
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Astrid Glaser
Amino acid transport: a new target for regulating immune cell function and preventing type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Tom Brodnicki & Prof Helen Thomas
Cancer drug discovery by inhibition of a DNA repair pathway with Crispr/Cas9 gene editing and biochemistry
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Wayne Crismani
Machine learning of evolutionary forces within families using single-cell sequencing
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Wayne Crismani & Dr Davis McCarthy
What are the functional properties of human CD4+ T cells, from people with type 1 diabetes, that respond to proinsulin C-peptide?
Disease Focus: Type 1 diabetes
Project Type: PhD
Supervisor(s): A/Prof Stuart Mannering
What antigens/epitopes are recognized by islet-infiltrating CD8+ T cells in people with type 1 diabetes?
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering
Using the JAK1/JAK2 inhibitor baricitinib to treat new-onset type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): Prof Helen Thomas
Understanding how type 17 immunity and IL-17 cytokines regulate type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): Dr Andrew Sutherland
The cellular fuel gauge: Novel mechanisms of metabolic control
Disease Focus: Type 2 diabetes
Project Type: PhD/Honours
Supervisor(s): A/Prof Jonathan Oakhill & Dr John W Scott
Structural biology of proteins involved in neurodegenerative disorders and mental illness
Disease Focus: Neurodegeneration
Project Type: PhD/Honours
Supervisor(s): Prof Michael Parker & Dr Jonathan Gooi
Investigating cardiovascular disease in Friedreich’s ataxia using human induced pluripotent stem cells
Disease Focus: Rare diseases, Heart disease
Project Type: PhD/Honours
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees
How to detect a T cell’s response to autoantigen?
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering
Factors that determine islet antigen-specific T-cell expansion before the onset of type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD
Supervisor(s): Prof Helen Thomas & Dr Bala Krishnamurthy
Engineering a tissue flap
Disease Focus:
Project Type: Honours
Supervisor(s): A/Prof Geraldine Mitchell
Drug development for metabolic diseases
Disease Focus: Type 2 diabetes, Cancer, Heart disease
Project Type: PhD/Honours
Supervisor(s): A/Prof Jonathan Oakhill & Prof Bruce E. Kemp
How are autophagic processes involved in bone mineralisation?
Disease Focus: Osteoporosis
Project Type: Honours
Supervisor(s): Prof Natalie Sims
What controls the development of strong cortical bone?
Disease Focus: Osteoporosis
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Natalie Sims & Dr Natalie Wee