UP
Student Research Projects
T cell exhaustion in autoimmune diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Gaurang Jhala
New approaches to beta-cell replacement
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): Prof Helen Thomas
Recurrence of type 1 diabetes in transplanted autologous beta cells
Disease Focus: Type 1 diabetes
Project Type: PhD
Supervisor(s): Prof Helen Thomas
Cancer mutation processes driven by stability of DNA:RNA hybrids
Disease Focus: Cancer
Project Type: PhD/Honours
Supervisor(s): A/Prof Andrew Deans
Application of gene editing to the study of inherited breast and ovarian cancer
Disease Focus: Cancer
Project Type: PhD/Honours
Supervisor(s): A/Prof Andrew Deans & A/Prof Wayne Crismani
A precise method for CRISPR gene editing through activation of DNA repair
Disease Focus: Rare diseases
Project Type: PhD/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Astrid Glaser
STAT3 signaling and the role of stromal-vascular communication in the development of cortical bone
Disease Focus: Osteoporosis
Project Type: PhD
Supervisor(s): Prof Natalie Sims
Activating KIR in health and disease
Disease Focus:
Project Type: PhD/Honours
Supervisor(s): Dr Julian Vivian
KIR3DL1 in acute myeloid leukaemia.
Disease Focus: Cancer
Project Type: PhD/Honours
Supervisor(s): Dr Julian Vivian
Identifying new HIPs using by screening an antigen library
Disease Focus: Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Stuart Mannering & Dr Pushpak Bhattacharjee
Dissecting the antigen specificity of responding CD4+ T cells in a CFSE-based proliferation assays
Disease Focus: Type 1 diabetes
Project Type: Masters/Honours
Supervisor(s): A/Prof Stuart Mannering & Dr Pushpak Bhattacharjee
How are lysosomal processes involved in bone mineralisation?
Disease Focus: Osteoporosis
Project Type: Honours
Supervisor(s): Prof Natalie Sims
What controls the development of strong cortical bone?
Disease Focus: Osteoporosis
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Natalie Sims
Understanding the function of the DNA helicase RECQL4 in normal and cancer biology
Disease Focus: Rare diseases
Project Type: Masters/PhD
Supervisor(s): Dr Monique Smeets & Prof Carl Walkley
Identifying IL-27 dependent pathogenic mechanisms in Type 1 Diabetes
Disease Focus: Type 1 diabetes
Project Type: Masters/Honours
Supervisor(s): Dr Andrew Sutherland
Mechanisms of Regulatory T cell action in Type 1 Diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Andrew Sutherland
Complex liver organoids
Disease Focus:
Project Type: Honours
Supervisor(s): A/Prof Geraldine Mitchell & Dr Kiryu Yap, RA and PhD student
Mapping the cellular network that regulates immunogenicity of self nucleic acids
Disease Focus: Rare diseases
Project Type: Masters/PhD
Supervisor(s): Dr Jacki Heraud-Farlow & Prof Carl Walkley
Activation of nucleolar-specific DNA damage response as a therapeutic strategy for ovarian cancer
Disease Focus: Cancer
Project Type: Masters/Honours
Supervisor(s): A/Prof Elaine Sanij
Regulation of blood cell production by endothelial cell-derived retinoic acid receptor gamma
Disease Focus: Cancer
Project Type: Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin
Identifying better therapies for patients with myelodysplastic syndromes
Disease Focus: Cancer
Project Type: PhD/Honours
Supervisor(s): Prof Louise Purton
The impact of cancer therapies on the bone marrow microenvironment
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin
How do bone marrow microenvironments regulate B lymphocyte production?
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Louise Purton & Dr Gavin Tjin
Developing a new drug with anticancer and cardioprotective dual therapeutic effects
Disease Focus: Cancer, Heart disease
Project Type: Masters/PhD
Supervisor(s): Dr Shiang (Max) Lim
Modelling cardiovascular diseases using human cardiac organoids
Disease Focus: Heart disease, Type 2 diabetes
Project Type: Masters/PhD
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees (Post-doctoral Fellow)
How does the periosteum control bone width?
Disease Focus: Osteoporosis
Project Type: PhD/Masters/Honours
Supervisor(s): Prof Natalie Sims & Dr Natalie Wee
Benchmarking of data reconstruction methods in single-cell genomics
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Deep learning for clinical image data
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
New methods to study tumour heterogeneity with single-cell genomic data
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Statistical methods and software for population-scale single-cell genetics
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Investigating a novel mechanism for improving beta-cell function in type 2 diabetes
Disease Focus: Type 2 diabetes
Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh
The role of AMP-activated kinase in suppressing atherosclerosis
Disease Focus: Heart disease
Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh
Structure-based drug design of selective Drp1 inhibitors
Disease Focus: Cancer, Neurodegeneration, Heart disease
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Christopher Langendorf
Amino acid transport: a new target for regulating immune cell function and preventing type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Tom Brodnicki & Prof Helen Thomas
Cancer drug discovery by inhibition of a DNA repair pathway with Crispr/Cas9 gene editing and biochemistry
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Wayne Crismani
Machine learning of evolutionary forces within families using single-cell sequencing
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Wayne Crismani & Dr Davis McCarthy
What are the functional properties of human CD4+ T cells, from people with type 1 diabetes, that respond to proinsulin C-peptide?
Disease Focus: Type 1 diabetes
Project Type: PhD
Supervisor(s): A/Prof Stuart Mannering
What antigens/epitopes are recognized by islet-infiltrating CD8+ T cells in people with type 1 diabetes?
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering
Understanding the functions of IL-17 family receptors in type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Andrew Sutherland
The cellular fuel gauge: Novel mechanisms of metabolic control
Disease Focus: Type 2 diabetes, Cancer, Heart disease
Project Type: PhD/Honours
Supervisor(s): A/Prof Jon Oakhill
Structural biology of proteins involved in neurodegenerative disorders and mental illness
Disease Focus: Neurodegeneration
Project Type: PhD/Honours
Supervisor(s): Prof Michael Parker & Dr Jonathan Gooi
Investigating cardiovascular disease in Friedreich’s ataxia using human induced pluripotent stem cells
Disease Focus: Rare diseases, Heart disease
Project Type: Masters/PhD
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees (Post-doctoral Fellow)
How to detect a T cell’s response to autoantigen?
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering
Drug development for metabolic diseases
Disease Focus: Type 2 diabetes, Cancer, Heart disease
Project Type: PhD/Honours
Supervisor(s): A/Prof Jon Oakhill & Prof Bruce E. Kemp