UP
Student Research Projects
Benchmarking of data reconstruction methods in single-cell genomics
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Studying RNA methylation and splicing in cancer with direct RNA nanopore sequencing
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Deep learning for clinical image data
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
New methods to study tumour heterogeneity with single-cell genomic data
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Statistical methods and software for population-scale single-cell genetics
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy
Investigating a novel mechanism for improving beta-cell function in type 2 diabetes
Disease Focus: Type 2 diabetes
Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh
The role of AMP-activated kinase in suppressing atherosclerosis
Disease Focus: Heart disease
Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh
Structure-based drug design of selective Drp1 inhibitors
Disease Focus: Cancer, Alzheimer’s disease, Heart disease
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Jess Holien & Dr Christopher Langendorf
Identification of novel therapeutic targets in mucinous ovarian cancer
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Jess Holien
Inhibition of microglia inflammation by AMPK for obesity treatment
Disease Focus: Type 2 diabetes
Project Type: PhD
Supervisor(s): Dr Sandra Galic & Prof Bruce E. Kemp
Function and structure of the breast cancer predisposition gene BRCA1
Disease Focus: Cancer
Project Type: PhD/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Rohan Bythell-Douglas
The role of the FANCM gene in inherited breast cancer
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Elyse Dunn
The role of RecQL4 gene in cancer predisposition
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans & A/Prof Carl Walkley
Improved gene editing by CRISPR/Cas9
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Astrid Glaser
Extracellular vesicles to guide therapy development in heart disease
Disease Focus: Heart disease
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Shiang (Max) Lim
A role for long non-coding RNAs (lncRNAs) in regulating dendritic cell function and preventing autoimmune disease
Disease Focus: Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Tom Brodnicki
Amino acid transport: a new target for regulating immune cell function and preventing type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Tom Brodnicki & Prof Helen Thomas
Cancer drug discovery by inhibition of a DNA repair pathway with Crispr/Cas9 gene editing and biochemistry
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Wayne Crismani
Machine learning of evolutionary forces within families using single-cell sequencing
Disease Focus: Cancer
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Wayne Crismani & Dr Davis McCarthy
Transgenerational influence of diet on autoimmune susceptibility
Disease Focus: Type 1 diabetes
Project Type: PhD
Supervisor(s): A/Prof Mark Chong
What are the functional properties of human CD4+ T cells, from people with type 1 diabetes, that respond to proinsulin C-peptide?
Disease Focus: Type 1 diabetes
Project Type: PhD
Supervisor(s): A/Prof Stuart Mannering
What antigens/epitopes are recognized by islet-infiltrating CD8+ T cells in people with type 1 diabetes?
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering
Using the JAK1/JAK2 inhibitor baricitinib to treat new-onset type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): Prof Helen Thomas
Understanding how type 17 immunity and IL-17 cytokines regulate type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): Dr Andrew Sutherland
The role of the non-muscle myosin component Myl9 in embryonic development and haematopoietic stem cell function
Disease Focus: Cancer
Project Type: PhD/Honours
Supervisor(s): A/Prof Mark Chong
The cellular fuel gauge: Novel mechanisms of metabolic control
Disease Focus: Type 2 diabetes
Project Type: PhD/Honours
Supervisor(s): A/Prof Jonathan Oakhill & Dr John W Scott
Structural biology of proteins involved in mental illnesses
Disease Focus: Alzheimer’s disease
Project Type: PhD/Honours
Supervisor(s): Prof Michael Parker
Regulation of ghrelin signalling by AMPK
Disease Focus: Type 2 diabetes, Heart disease
Project Type: PhD/Honours
Supervisor(s): Dr Sandra Galic & Prof Bruce E. Kemp
Modelling diabetic-induced cardiomyopathy using human cardiac organoids
Disease Focus: Heart disease, Type 2 diabetes, Type 1 diabetes
Project Type: PhD/Masters/Honours
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees
Investigating cardiovascular disease in Friedreich’s ataxia using human induced pluripotent stem cells
Disease Focus: Heart disease
Project Type: PhD/Honours
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees
Inhibiting hypoxia and inflammation-induced damage to improve the outcomes of islet transplantation
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): Dr Michaela Waibel & Prof Helen Thomas
How to detect a T cell’s response to autoantigen?
Disease Focus: Type 1 diabetes
Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering
Factors that determine islet antigen-specific T-cell expansion before the onset of type 1 diabetes
Disease Focus: Type 1 diabetes
Project Type: PhD
Supervisor(s): Prof Helen Thomas & Dr Bala Krishnamurthy
Engineering a tissue flap
Disease Focus: Cancer
Project Type: Honours
Supervisor(s): A/Prof Geraldine Mitchell
Drug development for metabolic diseases
Disease Focus: Type 2 diabetes, Cancer, Heart disease
Project Type: PhD/Honours
Supervisor(s): A/Prof Jonathan Oakhill & Prof Bruce E. Kemp