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Student Research Projects

Benchmarking of data reconstruction methods in single-cell genomics

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

Studying RNA methylation and splicing in cancer with direct RNA nanopore sequencing

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

Deep learning for clinical image data

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

New methods to study tumour heterogeneity with single-cell genomic data

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

Statistical methods and software for population-scale single-cell genetics

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Davis McCarthy

Investigating a novel mechanism for improving beta-cell function in type 2 diabetes

Disease Focus: Type 2 diabetes

Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh

The role of AMP-activated kinase in suppressing atherosclerosis

Disease Focus: Heart disease

Project Type: PhD/Honours
Supervisor(s): Dr Kim Loh

Structure-based drug design of selective Drp1 inhibitors

Disease Focus: Cancer, Alzheimer’s disease, Heart disease

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Jess Holien & Dr Christopher Langendorf

Identification of novel therapeutic targets in mucinous ovarian cancer

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Jess Holien

Inhibition of microglia inflammation by AMPK for obesity treatment

Disease Focus: Type 2 diabetes

Project Type: PhD
Supervisor(s): Dr Sandra Galic & Prof Bruce E. Kemp

Function and structure of the breast cancer predisposition gene BRCA1

Disease Focus: Cancer

Project Type: PhD/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Rohan Bythell-Douglas

The role of the FANCM gene in inherited breast cancer

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Elyse Dunn

The role of RecQL4 gene in cancer predisposition

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans & A/Prof Carl Walkley

Improved gene editing by CRISPR/Cas9

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): A/Prof Andrew Deans & Dr Astrid Glaser

Extracellular vesicles to guide therapy development in heart disease

Disease Focus: Heart disease

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Shiang (Max) Lim

A role for long non-coding RNAs (lncRNAs) in regulating dendritic cell function and preventing autoimmune disease

Disease Focus: Type 1 diabetes

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Tom Brodnicki

Amino acid transport: a new target for regulating immune cell function and preventing type 1 diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Tom Brodnicki & Prof Helen Thomas

Cancer drug discovery by inhibition of a DNA repair pathway with Crispr/Cas9 gene editing and biochemistry

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Wayne Crismani

Machine learning of evolutionary forces within families using single-cell sequencing

Disease Focus: Cancer

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Wayne Crismani & Dr Davis McCarthy

Transgenerational influence of diet on autoimmune susceptibility

Disease Focus: Type 1 diabetes

Project Type: PhD
Supervisor(s): A/Prof Mark Chong

What are the functional properties of human CD4+ T cells, from people with type 1 diabetes, that respond to proinsulin C-peptide?

Disease Focus: Type 1 diabetes

Project Type: PhD
Supervisor(s): A/Prof Stuart Mannering

What antigens/epitopes are recognized by islet-infiltrating CD8+ T cells in people with type 1 diabetes?

Disease Focus: Type 1 diabetes

Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering

Using the JAK1/JAK2 inhibitor baricitinib to treat new-onset type 1 diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD/Honours
Supervisor(s): Prof Helen Thomas

Understanding how type 17 immunity and IL-17 cytokines regulate type 1 diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD/Honours
Supervisor(s): Dr Andrew Sutherland

The role of the non-muscle myosin component Myl9 in embryonic development and haematopoietic stem cell function

Disease Focus: Cancer

Project Type: PhD/Honours
Supervisor(s): A/Prof Mark Chong

The cellular fuel gauge: Novel mechanisms of metabolic control

Disease Focus: Type 2 diabetes

Project Type: PhD/Honours
Supervisor(s): A/Prof Jonathan Oakhill & Dr John W Scott

Structural biology of proteins involved in mental illnesses

Disease Focus: Alzheimer’s disease

Project Type: PhD/Honours
Supervisor(s): Prof Michael Parker

Regulation of ghrelin signalling by AMPK

Disease Focus: Type 2 diabetes, Heart disease

Project Type: PhD/Honours
Supervisor(s): Dr Sandra Galic & Prof Bruce E. Kemp

Modelling diabetic-induced cardiomyopathy using human cardiac organoids

Disease Focus: Heart disease, Type 2 diabetes, Type 1 diabetes

Project Type: PhD/Masters/Honours
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees

Investigating cardiovascular disease in Friedreich’s ataxia using human induced pluripotent stem cells

Disease Focus: Heart disease

Project Type: PhD/Honours
Supervisor(s): Dr Shiang (Max) Lim & Dr Jarmon Lees

Inhibiting hypoxia and inflammation-induced damage to improve the outcomes of islet transplantation

Disease Focus: Type 1 diabetes

Project Type: PhD/Honours
Supervisor(s): Dr Michaela Waibel & Prof Helen Thomas

How to detect a T cell’s response to autoantigen?

Disease Focus: Type 1 diabetes

Project Type: PhD/Honours
Supervisor(s): A/Prof Stuart Mannering

Factors that determine islet antigen-specific T-cell expansion before the onset of type 1 diabetes

Disease Focus: Type 1 diabetes

Project Type: PhD
Supervisor(s): Prof Helen Thomas & Dr Bala Krishnamurthy

Engineering a tissue flap

Disease Focus: Cancer

Project Type: Honours
Supervisor(s): A/Prof Geraldine Mitchell

Drug development for metabolic diseases

Disease Focus: Type 2 diabetes, Cancer, Heart disease

Project Type: PhD/Honours
Supervisor(s): A/Prof Jonathan Oakhill & Prof Bruce E. Kemp