Activating KIR in health and disease
The projects centre broadly on the role of Natural Killer Cell receptors in the control of HIV replication. It is well established that KIR receptors are grouped into activating and inhibitory sub-types that together dictate the cellular immune response. Yet, how these two receptor sub-types differ in terms of ligand recognition and coordinate signaling and how this plays out with regard to sensing and controlling HIV infection is unknown. We are interested in characterising these receptors at the cellular, molecular and atomic level.
Dr Julian Vivian
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