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AMPK regulation of lipid metabolism

AMPK regulation of lipid metabolism

PhD/Honours project

AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC) isoforms 1 and 2, key mediators of fatty acid metabolism. We have generated single and double knock-in mouse lines with Ser to Ala mutations for the individual AMPK phosphorylation sites on ACC 1 and 2. These mice can no longer control cellular malonyl-CoA concentrations in response to AMPK signaling, nor do they respond to metformin when placed on a high fat diet. The project will aim to further characterize phenotypic changes associated with ACC knock in mice.

Supervised by:

  • Prof Bruce E. Kemp
  • Dr John W. Scott
  • Dr Jonathan Oakhill
  • Dr Sandra Galic
  • Disease Focus:

  • Type 2 diabetes
  • Research Unit:

  • Protein chemistry & metabolism