Careers & Students

Cancer drug discovery by inhibition of a DNA repair pathway

Cancer drug discovery by inhibition of a DNA repair pathway

PhD/Honours project

Want to cure cancer? We do too. Join our dynamic young team of experts, in the identification and characterisation of new potential cancer therapeutics. In this project, you would learn about DNA repair, genetic diseases and a variety of laboratory-based techniques (AlphaScreen drug discovery assays, recombinant DNA technology, CRISPR gene targeting, drug discovery, cell-based chemotherapy response assays, pharmacokinetics, protein purification and in vitro enzyme assays).

Chemotherapy is one of the essential tools in modern cancer treatment. Chemotherapy works by creating DNA damage in cancer cells, but tumour cells can gain resistance by upregulating DNA repair pathways. Our team has made major breakthroughs in reconstituting these DNA repair reactions in vitro, allowing a new approach to design DNA repair-inhibiting drugs. This approach may identify sensitisers that would make these “untreatable” cancers receptive to traditional chemotherapies. By joining us you will gain exposure to basic and translational research that is at the forefront internationally. You will receive training in a molecular biology laboratory with a focus on biochemistry and cell biology, increase your understanding of cancer biology and treatment, and increase your employability particularly in the science sector.

$5,000 PhD top ups and honours scholarships are available to a limited number of outstanding candidates. Scholarships are awarded on a competitive basis.

Van Twest et al, Molecular Cell 2017, 65(2):247-259
Ceccaldi et al, Nature Reviews Molecular Cell Biology 2016, 17:337–349

Supervised by:

  • Dr Wayne Crismani
  • Disease Focus:

  • Cancer
  • Research Unit:

  • Genome stability