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Circular RNAs and dendritic cell responses to TLR ligands

Circular RNAs and dendritic cell responses to TLR ligands

PhD/Honours project

Circular RNAs are a recently discovered class of non-coding RNAs that are derived from back-splicing of exons and/or introns of messenger RNAs. They are thought to have important regulatory functions. Some circRNAs have been shown to function as sponges for microRNAs, although others may function via alternate mechanisms. Dendritic cells are specialised antigen presenting cells that are critical for driving immune responses. For this to occur, they must be able to respond appropriately to danger stimuli, such as various pathogen-associated molecular patterns. This project will investigate whether circRNAs have a role in modulating dendritic cell responses to Toll-like receptor ligands. The expression of circRNAs in dendritic cells will by mapped by constructing RNaseA-resistant RNAseq libraries. To determine if specific circRNAs do indeed regulate the response of dendritic cells to TLR ligands, the impact of knocking down these circRNAs will be investigated.

Supervised by:

  • Associate Professor Mark Chong
  • Disease Focus:

  • Cancer
  • Research Unit:

  • Genomics & immunology