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Creating human capillary networks derived from adult human stem cells

Creating human capillary networks derived from adult human stem cells

PhD/Honours project

The project will explore the use of human induced pluripotent stem cells (iPSC) derived endothelial cells and vascular smooth muscle cells to form human capillary networks in porous scaffolds in vitro for transplantation into animal wound models. The project addresses the issue of disrupted blood vessel growth into many chronic wounds in diabetes and other peripheral ischaemia conditions, and in reconstructive surgery scenarios where there are no blood vessels in deep wounds over bone or tendon.  The use of iPSC cells allows adult stem cells to be generated from the patient which can be differentiated and expanded into the millions of autologous (compatible) endothelial cells and smooth muscle cells required for capillary network formation.

Supervised by:

  • A/Prof Geraldine Mitchell
  • Dr Shiang (Max) Lim
  • Disease Focus:

  • Cancer
  • Research Unit:

  • Vascular biology