Developing a new drug with anticancer and cardioprotective dual therapeutic effects
Chemotherapy medications can be extremely toxic to the heart and even if patients survive, they are up to 15 times more likely to develop heart failure. Our lab has a new drug that can protect the heart from injury and, excitingly, may also have anticancer properties. This new drug is a selective small molecule inhibitor of Drp1, which is a mitochondrial fission protein that regulates mitochondrial shape and connectivity, mitochondrial function, cell death and cancer cell proliferation. This project aims to examine the anticancer and cardioprotective effects of this new drug using different human cancer cell lines and human cardiomyocytes derived from induced pluripotent stem cells.
The knowledge and skills involved in this project are suitable for students who are interested in mitochondrial function, stem cell biology, cancer biology and heart disease. A student working on this project will have the opportunity to learn various experimental skills, including; cell culture, protein and gene analysis, histology and electrophysiology.
Primary Supervisor: Dr Shiang Lim; [email protected]
Co-supervisor: Dr Jessica Holien; [email protected]
Dr Shiang (Max) Lim
For further information about this project, contact: