scroll
UP

Careers & Students

Does insulin expression in APCs prevent diabetes after autoimmunity is established?

Does insulin expression in APCs prevent diabetes after autoimmunity is established?

PhD/Honours project

In NOD mice, the best available mouse model of type 1 diabetes, peptides generated from beta cell proteins such as insulin, IGRP and GAD are important in activating T cells. Evidence suggests that insulin is an important protein because NOD mice can be protected from developing diabetes when T cells recognising insulin are deleted by genetically engineering NOD mice to express insulin in antigen-presenting cells (APCs). We are interested to know if expressing insulin in APCs after the disease process has already begun will protect NOD mice from diabetes. We have made transgenic NOD mice that express insulin in APCs under control of the tetracycline transactivator so that we can control the period during which insulin is expressed in APCs. Using this strategy, we can clarify if it is appropriate to employ a tolerance strategy directed towards insulin in high-risk humans to prevent type 1 diabetes.

Supervised by:

  • Prof Tom Kay
  • Disease Focus:

  • Type 1 diabetes
  • Research Unit:

  • Immunology