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How do IL-6 / gp130 family cytokines control cortical structure?

How do IL-6 / gp130 family cytokines control cortical structure?

PhD/Honours project

Most fractures associated with bone fragility (osteoporosis and osteopenia) occur through cortical bone, but the way that strong cortical bone forms is not understood. We have recently developed a new mouse model with defective cortical bone formation due to a defect in cytokine signalling in osteocytes. This project will use this mouse and cell culture systems to develop a new understanding of the way that cortical bone forms, and how it is regulated by sex steroid hormones. Approaches to be used will include the use of knockout mice, histology and histomorphometry, micro-computed tomography, cell culture, and molecular biology including PCR, Western blot and genotyping.

Supervised by:

  • A/Prof Natalie Sims
  • Disease Focus:

  • Osteoporosis
  • Research Unit:

  • Bone cell biology and disease