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How does PTHrP control cortical bone width?

How does PTHrP control cortical bone width?

PhD/Honours project

The fundamental mechanisms that control bone width, independent of length, are not known, even though there is great variation in bone width, and it is a major contributor to bone strength. If we can understand how bones become wide, we will be able to provide new ways to strengthen the skeleton in conditions of fragility and in fracture healing. We have recently discovered that parental PTHrP influences bone width, and this provides a model that we can use to discover how bone width is controlled. This project will use this mouse to develop a new understanding of the way that bone width is controlled, and how it is regulated by sex steroid hormones. Approaches to be used will include the use of knockout mice, histology and histomorphometry, micro-computed tomography, cell culture, and molecular biology including PCR, Western blot and genotyping.

Supervised by:

  • A/Prof Natalie Sims
  • Disease Focus:

  • Osteoporosis
  • Research Unit:

  • Bone cell biology and disease