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Improving current approaches to Alzheimer’s disease

Improving current approaches to Alzheimer’s disease

PhD/Honours project

Alzheimer's disease (AD) is the fourth biggest killer in developed countries. Amyloid precursor protein (APP) plays a central role in the development of AD, through generation of the toxic Abeta peptide by proteolytic breakdown of APP. Here we will use X-ray crystallography at the Australian Synchrotron to determine the 3D atomic structures of Abeta bound to therapeutic antibodies currently in clinical trials in order to understand how these molecules recognise Abeta. We use this information to engineer more potent antibodies as treatments for AD. We also have structure-based drug discovery projects on APP itself and other proteins involved in the production and clearance of the Abeta peptide from the brain

Supervised by:

  • Prof Michael Parker
  • Disease Focus:

  • Alzheimer’s disease
  • Research Unit:

  • Structural biology