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Intercellular communication between lymphatic endothelial cells and their extracellular environment

Intercellular communication between lymphatic endothelial cells and their extracellular environment

PhD project

Communication between cells is a fundamental process during disease progression. One of the key features of lymphodema is the accumulation of fat within the surrounding tissue, fibrosis, poor immunity and extreme pain. We would like to understand how adipocytes, nerve cells, fibroblasts and immune cells communicate with lymphatic endothelial cells during the course of lymphodema. The project will involve development of genetic animal models, cell biology and cell imaging and bioinformatics to understand the communication between different cell types in affected tissue.

Supervised by:

  • Dr Tara Karnezis
  • Dr Ramin Shayan
  • Disease Focus:

  • Cancer
  • Research Unit:

  • Lymphatic & regenerative surgery