Careers & Students

Physiological role of AMPK binding to glycogen

Physiological role of AMPK binding to glycogen

PhD/Honours project

The AMPK b subunit targets the enzyme to glycogen.   Mutations in AMPK that increase AMPK activity lead to the accumulation of glycogen which may increase exercise capacity in skeletal muscle but have deleterious effects on the electrical properties of the heart. Training will be provided in a number of techniques including molecular biology, protein biochemistry, protein expression and purification, mass spectrometry, primary cell culture, exercise physiology and genetic mouse models.

External available supervisor:
Nolan Hoffman

Supervised by:

  • Associate Professor Jonathan Oakhill
  • Dr John W. Scott
  • Dr Sandra Galic
  • Prof Bruce E. Kemp
  • Dr Christopher Langendorf
  • Disease Focus:

  • Heart disease
  • Type 2 diabetes
  • Research Unit:

  • Protein chemistry & metabolism