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Regulation of appetite by AMPK

Regulation of appetite by AMPK

PhD/Honours project

AMPK in the hypothalamus regulates food intake. The hormone ghrelin activates AMPK in the hypothalamus and stimulates appetite whereas the hormone leptin inhibits AMPK activity and suppresses appetite. We have generated mice that can no longer respond to leptin. Training will be provided in a number of techniques including molecular biology, protein biochemistry, protein expression and purification, mass spectrometry, primary cell culture, genetic mouse models.

Supervised by:

  • Dr John W. Scott
  • Dr Jonathan Oakhill
  • Dr Sandra Galic
  • Prof Bruce E. Kemp
  • Disease Focus:

  • Type 1 diabetes
  • Research Unit:

  • Protein chemistry & metabolism