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Regulation of CaMKK-2

Regulation of CaMKK-2

PhD/Honours project

CaMKK-2 is an important upstream kinase responsible for the phosphorylation and activation of AMPK as well as CaMK-I, CaMK-IV and SIRT-1. CaMKK-2 regulates a multitude of physiological functions that include whole-body energy homeostasis, appetite, inflammation and autophagy. Chronic activation of CaMKK-2 has been implicated in the pathogenesis of prostate and hepatic cancers, neurodegeneration, and obesity. On the other hand, reduced CaMKK-2 expression has been linked with schizophrenia and bipolar disorder in humans. This project is concerned with understanding how CaMKK-2 is regulated by multisite phosphorylation.

Training will be provided in a number of techniques including molecular biology, protein biochemistry, protein expression and purification, protein crystallography, mass spectrometry, primary cell culture, genetic mouse models.

Supervised by:

  • Prof Bruce E. Kemp
  • Dr John W. Scott
  • Dr Jonathan Oakhill
  • Dr Sandra Galic
  • Dr Christopher Langendorf
  • Disease Focus:

  • Type 2 diabetes
  • Research Unit:

  • Protein chemistry & metabolism