Structural biology of proteins involved in mental illnesses
Alzheimer’s disease (AD) is the fourth biggest killer in developed countries. Amyloid precursor protein (APP) plays a central role in the development of AD, through generation of the toxic Abeta peptide by proteolytic breakdown of APP. Here we will use X-ray crystallography at the Australian Synchrotron to determine the 3D atomic structures of Abeta bound to therapeutic antibodies currently in clinical trials in order to understand how these molecules recognise Abeta. We will use this information to engineer more potent antibodies as treatments for AD.
Prof Michael Parker
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