The role of RNA editing enzyme ADAR1 in liver homeostasis and metabolism
The gene ADAR1 is essential to perform a highly prevalent form of RNA modification termed A-to-I editing. Editing occurs primarily within repetitive elements in endogenous RNA that can fold to form immunogenic double-stranded RNA. When edited, this double-stranded RNA does not activate innate immune sensors. Mutation of ADAR1 however, leads to a profound upregulation of type I interferon in mice and humans and causes the severe auto-immune disease Aicardi-Goutieres syndrome. Recently, however, a novel function of Adar1 protein has been identified that is independent of its role in RNA editing. Preliminary results suggest a function in the liver to maintain normal metabolism. This project seeks to further investigate this function using mouse genetics, cell culture, RNA sequencing and biochemical techniques.
Dr Jacki Heraud-Farlow
Prof Carl Walkley
Cancer & RNA biology
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