The role of the non-muscle myosin component Myl9 in embryonic development and haematopoietic stem cell function
Previous studies from our laboratory discovered Myl9 as a novel regulator of haematopoietic stem cell (HSC) function. Dysregulated Myl9 expression causes a condition in mice similar to myelodysplastic syndrome, a pre-leukaemic pathology characterised by an inability of HSCs to continually replenish the cells of the immune system.
We recently generated a Myl9 knockout mouse model and discovered that it is also critical for late embryonic development, with most animals dying before birth. While it is clear that Myl9 has essential roles in haematopoiesis and embryonic development, its molecular mechanism of action remains unknown. Sequence similarity to other non-muscle myosin proteins suggests that Myl9 should function in that pathway, but this has yet to be proven. Thus, the goal of this project is to determine the molecular function of Myl9 and how it regulates haematopoiesis and development.
A/Prof Mark Chong
Genomics & immunology
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