Understanding how type 17 immunity and IL-17 cytokines regulate type 1 diabetes
Recent findings in our laboratory and others indicate that type 17 immune responses and IL-17 cytokines control the development of T1D in animal models. This project is focussed on identifying the underlying immune mechanisms and testing the therapeutic effects of immune inhibitors targeted against these pathways in T1D. The project will make use of both mouse and human systems including newly developed gene knockout NOD mice, novel immune inhibitors, CRISPR/Cas9 gene editing, cellular and molecular immunology techniques, pancreatic islet isolation, RNA-seq and flow cytometry.
In addition to SVI Top-Up Scholarships, students working on this project may be eligible for top-up awards from the Australian Juvenile Diabetes Research Foundation.
Dr Andrew Sutherland
Type 1 diabetes
For further information about this project, contact: