What controls the development of strong cortical bone?
Even though we know many signalling pathways that control closure of skull sutures after birth, the processes involved in forming the characteristic thickened cortical bone of the skull are poorly described.
We have developed a range of mouse models that will allow us to study the processes by which the thickened bone of the skull forms, and consolidates into two separate layers. These mice include strains with normal, porous, or thickened calvarial structures. In this project, you will carry out 3 dimensional micro-computed tomographic analysis to identify how skull formation changes in these mice over time, and will use histology to identify the cells and signalling pathways responsible.
This project will use small animal techniques, histology and histomorphometry, micro-computed tomography, immunohistochemistry, and possibly molecular biology, quantitative PCR, Western blot, and bone cell culture techniques.
Prof Natalie Sims
Dr Natalie Wee
Bone cell biology & disease
For further information about this project, contact: