What controls the development of strong cortical bone?
Age-related osteoporosis occurs, in part, because the vascular pores within the hardened outer shell of bone (the cortex) become larger with age, especially in regions of the skeleton that are less important for human activity. This project will identify how this occurs by studying the Melbourne Femur Research Collection, a unique forensic collection of human femur bones from subjects across the entire adult age range. We will identify regions of bone loss by micro-computed tomography, index the cell populations within the pores by histology, and measure the composition of the bone that remains by synchrotron-based infra-red spectroscopy. This project is supervised by Prof Natalie Sims at SVI and Dr Rita Hardiman (The University of Melbourne Dental School).
Prof Natalie Sims
Bone cell biology & disease
For further information about this project, contact: