While we know that high fat diets increase fatty acid metabolites, their role in metabolic dysfunction is poorly understood.
We have identified a shared region – a ‘molecular fingerprint’ – in more than 200 proteins, each involved in myriad bodily processes.
Crucially, we have found the fingerprint for a group of proteins involved in appetite and whole-body energy production. Our research seeks to understand how fat molecules can hijack protein function and determine if the molecular fingerprint predisposes proteins to be controlled by fat.
Dr Langendorf and colleagues hope to be able to transform our understanding of energy regulation and appetite control, and gain insights into genome-wide control by fat molecules – helping set Australia on a path to a healthier future