Research Unit
Molecular genetics
Information
Head, Molecular Genetics Unit
Associate Professor, Dept of Medicine SVH, The University of Melbourne
Professional Experience
1992 Medical School Graduate, University of Hamburg, Germany.
1993 Doctor of Medicine (summa cum laude), University of Hamburg, Germany
1995 Postdoctoral Training, Mount Sinai School of Medicine, New York
Achievements
1987 Friedrich-Ebert-Stiftung Scholarship (until 1992)
1993 HFSP Long-term Fellowship (until 1995)
1995 German Research Council (DFG) Fellowship (until 1997)
1998 NHMRC R.D. Wright Career Development Award (1998-2001)
1999 Australian Academy of Sciences International Travel Award
2002 NHMRC Senior Research Fellowship (2002-2006)
2007 NHMRC Senior Research Fellowship (2007-2011)
2012 NHMRC Senior Research Fellowship Level B (2012-2016)
2016 World-Wide Cancer Research Grant (2016-18)
Research Interests
Molecular mechanisms of carcinogenesis and normal development; B cells; protein-protein interactions; DNA damage responses; cilia; Zinc-finger proteins.
Selected Publications
- Heierhorst J, Kobe B, Feil SC, Parker MW, Benian GM, Weiss KR & Kemp BE (1996). Ca2+/S100 regulation of giant protein kinases. Nature 380, 636-39
- McNees CJ, Conlan LA, Tenis N & Heierhorst J (2005). ASCIZ regulates lesion-specific RAD51 focus formation and apoptosis after methylating DNA damage. EMBO J. 24, 2447-2457.
- Traven A & Heierhorst J (2005). SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA damage response proteins. BioEssays 27, 397-407.
- Hammet A, Magill C, Heierhorst J & Jackson SP (2007). Rad9 BRCT domains interact with phosphorylated H2AX to regulate the G1 checkpoint in budding yeast. EMBO Rep. 8, 851-857.
- Lee H, Yuan C, Hammet A, Mahajan A, Wu MR, Chen ESW, Su MI, Heierhorst J* & Tsai MD (2008). Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol. Cell 30, 767-778. (*co-senior author)
- Jurado S, Gleeson K, O'Donnell K, Izon DJ, Walkley CR, Strasser A, Tarlinton DM & Heierhorst J (2012). The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. J. Exp. Med. 209, 1629-1639.
- Hoch NC, Chen ESW, Buckland R, Wang SC, Fazio A, Hammet A, Pellicioli A, Chabes A, Tsai MD & Heierhorst J (2013). Molecular basis of the essential S phase function of the Rad53 checkpoint kinase. Mol. Cell. Biol. 33, 3202-3213.
- Wong DM, Li L, Jurado S, King A, Bamford R, Wall M, Walia MK, Kelly GL, Walkley KR, Tarlinton DM, Strasser A & Heierhorst J (2016). The transcription factor ASCIZ and its target DYNLL1 are essential for the development and expansion of MYC-driven B cell lymphoma. Cell Reports 14, 1488-1499.
- van Twest S, Murphy V, Hodson C, Tan, W, Swuec P, O'Rourke J, Heierhorst J, Crismani W & Deans AJ (2017). Mechanism of ubiquination and deubiquination in the Fanconi anemia pathway. Mol. Cell 65, 247-259.
- King A, Li L, Wong DM, Liu R, Bamford R, Strasser A, Tarlinton DM & Heierhorst J (2017). Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms. PLOS Genetics 13, e1007010.