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UP

A/Prof Natalie Sims

Research Unit

Bone cell biology and disease

Information

Head, Bone Cell Biology and Disease Unit
Deputy Director, SVI
nsims@svi.edu.au

Professional Experience

1991           BSc (Hons) The University of Adelaide, South Australia
1995           PhD The University of Adelaide, South Australia

Achievements

2018-2021       Associate Editor, Journal of Bone and Mineral Research
2018-2023       Associate Editor, Endocrine Reviews
2017-2019       President-Elect, Australia and New Zealand Bone and Mineral
                        Society
2016-2021       Editor, Journal of Biological Chemistry
2014-2018       Senior Editor, Bone             
2013                Herbert A Fleisch Award, International Bone and Mineral Society
2010                Fuller-Albright Award, American Society of Bone and Mineral
                        Research
2009-              Associate Professor, Principal Research Fellow, The University of
                        Melbourne, Department of Medicine at St. Vincent’s Hospital,
                        Melbourne, Australia

Research Interests

Research goal: to identify new pathways for treatment of bone disease by studying intercellular communication within the bone microenvironment, particularly the communication between osteoblasts (bone forming cells), osteoclasts (bone resorbing cells), and the internal network of cells within the bone matrix (osteocytes).

My laboratory collaborates widely and is internationally recognised for our expertise in the  study of gene knockout animals and animal models of destructive bone diseases. Our methods include histology, histomorphometry, micro-computed tomography, Fourier-transform infrared microscopy, immunohistochemistry, confocal immunofluorescence, cell culture and molecular biology techniques.

Selected Publications

  1. Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein. Ansari N, Ho PW, Crimeen-Irwin B, Poulton IJ, Brunt AR, Forwood MR, Divieti Pajevic P, Gooi JH, Martin TJ, Sims NA. Journal of Bone and Mineral Research. 2018 Jan;33(1):137-153. doi: 10.1002/jbmr.3291.
  2. Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6. Cho DC, Brennan HJ, Johnson RW, Poulton IJ, Gooi JH, Tonkin BA, McGregor NE, Walker EC, Handelsman DJ, Martin TJ, Sims NA. Nature Communications. 2017 Oct 9;8(1):806. doi: 10.1038/s41467-017-00920-x.
  3. Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation. Vrahnas C, Pearson TA, Brunt AR, Forwood MR, Bambery KR, Tobin MJ, Martin TJ, Sims NA. Bone. 2016 Dec;93:146-154. doi: 10.1016/j.bone.2016.09.022.
  4. Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. Walker EC, Johnson RW, Hu Y, Brennan HJ, Poulton IJ, Zhang JG, Jenkins BJ, Smyth GK, Nicola NA, Sims NA. Journal of Biological Chemistry. 2016 Oct 7;291(41):21703-21716.
  5. Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption. Sims NA. International Journal of Biochemistry and Cell Biology. 2016 Oct;79:14-23. doi: 10.1016/j.biocel.2016.08.003. Review.
  6. Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification. Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA. Development. 2016 Feb 15;143(4):648-57. doi: 10.1242/dev.125625. Epub 2016 Jan 11.
  7. Quantifying the osteocyte network in the human skeleton. Buenzli PR, Sims NA. Bone. 2015 Jun;75:144-50. doi: 10.1016/j.bone.2015.02.016.
  8. The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation. Ng AJ, Walia MK, Smeets MF, Mutsaers AJ, Sims NA, Purton LE, Walsh NC, Martin TJ, Walkley CR. PLoS Genetics. 2015 Apr 10;11(4):e1005160. doi: 10.1371/journal.pgen.1005160
  9. Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes. Chia LY, Walsh NC, Martin TJ, Sims NA. Bone. 2015 Mar;72:34-42. doi: 10.1016/j.bone.2014.11.005. Epub 2014 Nov 15.
  10. EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis. Tonna S, Takyar FM, Vrahnas C, Crimeen-Irwin B, Ho PW, Poulton IJ, Brennan HJ, McGregor NE, Allan EH, Nguyen H, Forwood MR, Tatarczuch L, Mackie EJ, Martin TJ, Sims NA. FASEB Journal. 2014 Oct;28(10):4482-96. doi: 10.1096/fj.14-254300. Epub 2014 Jun 30.
  11. The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation. Johnson RW, Brennan HJ, Vrahnas C, Poulton IJ, McGregor NE, Standal T, Walker EC, Koh TT, Nguyen H, Walsh NC, Forwood MR, Martin TJ, Sims NA. Journal of Bone and Mineral Research. 2014 Jun;29(6):1492-505. doi: 10.1002/jbmr.2159.