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A/Prof Stuart Mannering

Research Unit

Human Immunology

Information

Head, Immunology Laboratory

Professional Experience

1988     BSc Canterbury University, Christchurch, New Zealand
1994     M.Sc, University of Otago, Dunedin, New Zealand
1998     PhD, University of Otago, Dunedin, New Zealand
1998     Postdoctoral Fellow, University of Melbourne, Australia
2001     Postdoctoral Fellow, WEHI, Melbourne, Australia

Achievements

2006     JDRF Advanced Postdoctoral Fellowship
2009     JDRF Transition Award
2014     JDRF Career Development Award
2014     JDRF-Macquarie Group Foundation Diabetes Global Research Innovation               Award
2017     Diabetes Australia Millennium Award
2017    JDRF-Australia, T1D Clinical Research Network Innovation Award

Research Interests

My research interest is to understand how and why human T cells cause autoimmune diseases. Specifically, I am interested in understanding what antigens autoreactive T cells see and why those structures are recognised by auto-pathogenic T cells. How a T cell responds to a particular antigen changes the resulting immune response, hence I am interested in understanding what affects T cell function and in developing assays to detect autoantigen-specific T cells and analysing their function in vitro.

Selected Publications

  1. So, M., Elso, C. M., Tresoldi, E., Pakusch, M., Pathiraja, V., Wentworth, J. M., . . Mannering, S. I. (2018). Proinsulin C-peptide is an autoantigen in people with type 1 diabetes. Proc Natl Acad Sci U S A, 115(42), 10732-10737. doi:10.1073/pnas.1809208115
  2. Mannering, S. I., So, M., Elso, C. M., & Kay, T. W. H. (2018). Shuffling peptides to create T-cell epitopes: does the immune system play cards? Immunol Cell Biol, 96(1), 34-40. doi:10.1111/imcb.1015
  3. Mannering, S. I., Di Carluccio, A. R., & Elso, C. M. (2018). Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetes. Diabetologia. doi:10.1007/s00125-018-4760-6
  4. Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., . .Mannering, S., Haskins, K. (2016). Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science, 351(6274), 711-714. doi:10.1126/science.aad2791
  5. Pathiraja, V, Kuehlich JP, Campbell PD, Krishnamurthy B, Loudovaris T, Coates PT, Brodnicki TC, O'Connell PJ, Kedzierska K, Rodda C, Bergman P, Hill E, Purcell AW, Dudek NL, Thomas HE, Kay TW and Mannering SI (2015). "Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes." Diabetes 64(1): 172-182.
  6. Lopez, JA, Jenkins MR, Rudd-Schmidt JA, Brennan AJ, Danne JC, Mannering SI, Trapani JA and Voskoboinik I (2013). "Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse." J Immunol 191(5): 2328-2334.
  7. Joffe, M, Necula AS, Chand R, McWhinney BC, Krishnamurthy B, Loudovaris T, Goodman D, Thomas HE, Kay TW and Mannering SI (2012). "Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors." Int Immunol 24(7): 447-453.
  8. Broughton, SE, Petersen J, Theodossis A, Scally SW, Loh KL, Thompson A, van Bergen J, Kooy-Winkelaar Y, Henderson KN, Beddoe T, Tye-Din JA, Mannering SI, Purcell AW, McCluskey J, Anderson RP, Koning F, Reid HH and Rossjohn J (2012). "Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease." Immunity 37(4): 611-621.
  9. Moon HC, Joffe M, Thomas HE, Kay TW, Mannering SI. A method for extracting tissue proteins for use in lymphocyte function assays (2010). Journal of Immunological Methods 359, 56-60
  10. Mallone, R, Mannering SI, Brooks-Worrell BM, Durinovic-Bello I, Cilio CM, Wong FS and Schloot NC (2011). "Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society." Clin Exp Immunol 163(1): 33-49.
  11. Mannering, SI, Wong FS, Durinovic-Bello I, Brooks-Worrell B, Tree TI, Cilio CM, Schloot NC and Mallone R (2010). "Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes." Clin Exp Immunol 162(2): 197-209.(invited Review)
  12. Mannering SI, Pang SH, Williamson NA, Naselli G, Reynolds EC, O'Brien-Simpson NM, Purcell AW, Harrison LC, The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes. Clinical and experimental immunology 2009; 156: 226-31.