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UP

Dr Andrew Deans

Research Unit

Genome stability

Information

Victorian Cancer Agency (VCA) Mid Career Fellow
Head, Genome Stability Unit

Professional Experience

2000    BSc (Hons), biochemistry department, University of Melbourne.
2005    PhD, medicine department, University of Melbourne
05-06   Postdoctoral training, Peter MacCallum Cancer Institute, Melbourne
06-11    Postdoctoral Training, London Research Institute, UK

Achievements

2000-04    Cancer Council Victoria Postgraduate fellowship
2005-06    Cancer Council Victoria Postdoctoral fellowship
2006         Breast Cancer Campaign Postdoctoral fellowship (UK)
2007-13     NHMRC CJ Martin postdoctoral fellowship
2012-16     NBCF Early Career Fellowship

Research Interests

Familial breast/ovarian cancer; Fanconi Anaemia; Bloom’s Syndrome; DNA damage signalling and repair; regulation of ubiquitination; roles of DNA damage response proteins during chemotherapy.

Selected Publications

  1. Coulthard, R*, Deans, AJ*, Swuec, P, Bowles, M, Costa, A, West, SC, and McDonald, NQ ‘Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex’ Structure 2013 21, 1648-58
  2. Walden, H and Deans, AJ. ‘The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder’ Annual Review of Biophysics, 2014, 43:in press.
  3. Deans, AJ. ‘Fanconi proteins get histones moving’ EMBO J 2012 31 (17), 3511-3512
  4. ‘The DNA translocase activity of FANCM protects stalled replication forks’ AN Blackford, RA Schwab, J Nieminuszczy, AJ Deans, SC West, ... Human molecular genetics 2013 21:2005-2016
  5. Deans, AJ and West, SC. DNA interstrand crosslink repair and cancer. Nature Reviews Cancer 2011 11:467-480
  6. MacKay C, Déclais, AC, Lundin C, Agostinho A, Deans, AJ, MacArtney, TJ, Hofmann, K, Gartner, A, West, SC, Helleday, T, Lilley DMJ and Rouse, J. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2. Cell 2010 142:65-76
  7. Deans, AJ and West, SC. FANCM connects the genome instability disorders Bloom’s Syndrome and FanconiAnemia. Molecular Cell 2009 36, 943-953
  8. Spurdle AB, Deans AJ, Duffy D, Goldgar DE, Chen X, Beesley J; kConFaB, Easton DF, Antoniou AC, Peock, S, Cook M; EMBRACE Study Collaborators, Nathanson KL, Domchek SM, Macarthur GA, Chenevix-Trench G. No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 2009 115:307-13