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Dr Christopher Langendorf

Research Unit

Protein chemistry & metabolism

Information

Senior Research Officer, Protein Chemistry and Metabolism Unit

Professional Experience

2005            BSc. Hon Monash University
2005 -7        Research assistant, Monash University
2011-13        Research assistant, Monash University
2013 -15       Research assistant, Protein Chemistry and Metabolism Unit, SVI
2015             PhD Dept. Biochemistry and Molecular Biology, Monash University
2015 -17       Research officer, Protein Chemistry and Metabolism Unit, SVI
2018 -           Senior Research Officer, Protein Chemistry and Metabolism Unit

Achievements

2016 -18    Jack Brockhoff early career research grant
2017          EH Flack fellowship
2018 -       NHMRC early career research fellowship

Research Interests

Protein structure and function; X-ray crystallography; allosteric modulation of enzymes; signal transduction of allosteric signals; regulation of protein kinases involved in metabolism. 

Selected Publications

  1. Ling NXY, Kaczmarek A, Hoque A, Davie E, Ngoei KRW, Morrison KR, Smiles WJ, Forte GM, Wang T, Lie S, Dite TA, Langendorf CG, Scott JW, Oakhill JS, Petersen J (2020). mTORC1 Directly Inhibits AMPK to Promote Proliferation Under Nutrient Stress. Nature Metabolism 1(12).
  2. O’Byrne SN, Scott JW, Pilotte JR, Santiago AS, Langendorf CG, Oakhill JS, Eduful BJ, Counago RM, Wells CI, Zuercher WJ, Wilson TM and Drewry DH (2020). In Depth Analysis of Kinase Cross Screening Data to Identify CaMKK2 Inhibitory Scaffolds. Molecules 25(2).
  3. Dite TA, Langendorf CG, Hoque A, Galic S, Rebello RJ, Ovens AJ, Lindquist LM, Ngoei KRW, Ling NXY, Furic L, Kemp BE, Scott JW and Oakhill, JS (2018). AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965Journal of Biological Chemistry.
  4. Asquith CRM, Godoi PH, Counago RM, Laitinen T, Scott JW, Langendorf CG, Oakhill JS, Drewry DH, Zuercher WJ, Koutentis PA, Willson TM, and Kalogirou AS. (2018) 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors. Molecules 23.
  5. Ngoei KRW*, Langendorf CG*, Ling NXY, Hoque A, Johnson S, Camerino MC, Walker SR, Bozikis YE, Dite TA, Ovens AJ, Smiles WJ, Jacobs R, Huang H, Parker MW, Scott JW, Rider MH, Foitzik RC, Kemp BE, Baell JB and Oakhill JS (2018). Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK 221 by the Glucose Importagog SC4. Cell Chemical Biology.
  6. Langendorf, C. G., Ngoei, K. R. W., Scott, J. W., Ling, N. X. Y., Issa, S. M. A., Gorman, M. A., Parker, M. W., Sakamoto, K., Oakhill, J. S. and Kemp, B. E. (2016) Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nature Communications, 7:10912.
  7. Scott, J. W., Park, E., Rodriguiz, R. M., Oakhill, J. S., Issa, S. M., O'Brien, M. T., Dite, T. A., Langendorf, C. G., Wetsel, W. C., Means, A. R., and Kemp, B. E. (2015) Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. Sci Rep 5, 14436.
  8. Scott, J. W., Galic, S., Graham, K. L., Foitzik, R., Ling, N. X., Dite, T. A., Issa, S. M., Langendorf, C. G., Weng, Q. P., Thomas, H. E., Kay, T. W., Birnberg, N. C., Steinberg, G. R., Kemp, B. E., and Oakhill, J. S. (2015) Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release. Chem Biol 22, 705-711.
  9. Langendorf, C. G., and Kemp, B. E. (2015) Choreography of AMPK activation. Cell Research 25, 5-6.
  10. Scott, J. W., Oakhill, J. S., Ling, N. X., Langendorf, C. G., Foitzik, R. C., Kemp, B. E., and Issinger, O. G. (2014) ATP sensitive bi-quinoline activator of the AMP-activated protein kinase. Biochem Biophys Res Commun 443, 435-440.
  11. Scott, J. W., Ling, N., Issa, S. M., Dite, T. A., O'Brien, M. T., Chen, Z. P., Galic, S., Langendorf, C. G., Steinberg, G. R., Kemp, B. E., and Oakhill, J. S. (2014) Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling. Chem Biol 21, 619-627.
  12. Langendorf, C. G., Tuck, K. L., Key, T. L. G., Fenalti, G., Pike, R. N., Rosado, C. J., Wong, A. S. M., Buckle, A. M., Law, R. H. P. and Whisstock, J. C. (2013) Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-inactivates. Bioscience Reports 33, 133-144.
  13. Langendorf, C. G., Key, L. G., Fenalti, G., Kan, W-T., Buckle, A. M., Caradoc-Davies, T., Tuck, K. L., Law, R. H. P. and Whisstock, J. C. (2010) The X-ray crystal structure of Escherishia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions. PLoS ONE 5, 1-12.
  14. Fischer, K.*, Langendorf, C. G.*, Irving, J. A., Reynolds, S., Willis, C., Beckham, S., Law, R. H., Yang, S., Bashtannyk-Puhalovich, T. A., McGowan, S., Whisstock, J. C., Pike, R. N., Kemp, D. J., and Buckle, A. M. (2009) Structural mechanisms of inactivation in scabies mite serine protease paralogues. J Mol Biol 390, 635-645.
  15. Kaiserman, D., Buckle, A.M., Van Damme, P., Irving, J.A., Law, R.H.P., Matthews, A.Y., Bashtannyk-Puhalovich, T., Langendorf, C.G., Thompson, P., Vandekerckhove, J., Gevaert, K., Whisstock, J.C. and Bird, P.I. (2009). Structure of granzyme C reveals an unusual mechanism of protease autoinhibition. PNAS. 106 (16): 5587-5592.
  16. Law, R. H., Sofian, T., Kan, W. T., Horvath, A. J., Hitchen, C. R., Langendorf, C. G., Buckle, A. M., Whisstock, J. C., and Coughlin, P. B. (2008) X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin. Blood 111, 2049-2052.
  17. Fenalti, G.*, Law, R. H. P.*, Buckle, A. M.*, Langendorf, C. G., Tuck, K., Rosado, C. J., Faux, N. G., Mahmood, K., Hampe, C. S., Banga, J. P., Wilce, M., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R. N., Smith, A. I., Mackay, I. R., Rowley, M. J. and Whisstock, J. C. (2007) GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol 14, 280-286.