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Dr Julian Vivian

Research Unit

Structural immunobiology

Information

Head, Structural Immunology Laboratory
Email: [email protected]

Professional Experience

2008 – 2011              NHMRC Peter Doherty Postdoctoral Fellow,
                                  Monash University
2012                          Postdoctoral Fellow, Monash University
2013 – 2016              ARC DECRA Postdoctoral Fellow, Monash University
2016                          Postdoctoral Fellow, Monash University
2017 – 2021              Group Leader (Molecular Immunology)
                                  Dept. of Biochemistry, Monash University
2021-                         Victorian Cancer Agency Mid Career Fellow
2022 -                        Head, Structural Immunology Laboratory, SVI

Achievements

Research Interests

My career has focused on protein chemistry and protein imaging of molecules that are central to regulation and dysregulation of the immune system. I aim to uncover the mechanisms by which these molecules lead to disease susceptibility and disease progression and by corollary the mechanisms by which they can be harnessed to cure disease. In particular, I have focused on the immune effector cells T cells and Natural Killer cells that are able to surveille the body and detect and kill aberrant cells such as those transformed by viruses or cancer. Similarly, when these cells are dysregulated they can cause autoimmune diseases. My work spans cancers such as leukemias, virology including HIV and autoimmune disease including multiple sclerosis and psoriasis. I aim to develop the next generation of immunotherapies to treat these conditions.

Selected Publications

  1. Moradi, S., Stankovic, S., O’Connor, G.M., Pymm, P., MacLachlan, B.J., Faoro, C., Retière, C., Sullivan, L.C., Saunders, P.M., Widjaja, J., Cox-Livingstone, S., Rossjohn, J#., Brooks, A.G#., Vivian, J.P#. Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nature Communications. 12, 2173 (2021).
  2. Saunders P.M.*, MacLachlan B.J.*, Pymm P,  Illing P.T.,  Deng Y,  Wong S.C., Oates C.V.L,  Purcell A.W., Rossjohn J,  Vivian JP#,  Brooks A.G.# The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function Proceedings of the National Academy of Sciences (2020), 117 (21) 11636-11647.  
  3. Illing PT, Pymm P, Croft NP, Hilton HG, Jojic V, Han AS, Mendoza JL, Mifsud NA, Dudek NL, McCluskey J, Parham P, Rossjohn J, Vivian JP#, Purcell AW#. HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome. Nature Communications. 2018 Nov 8;9(1):4693.  

Note: #refers to joint senior authors.