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UP

Dr Kim Loh

Research Unit

Diabetes & metabolic disease

Information

Head, Diabetes and Metabolic Disease Laboratory
Email: [email protected]

Professional Experience

2008-12           PhD, Biochemistry & Molecular Biology, Monash University
2012-15           Research Officer, Neuroscience Division, Garvan Institute
2013-15           Conjoint Associate Lecturer, Faculty of Medicine, UNSW Australia
2015-19           Senior Research Officer, SVI
2018                ADS Skip-Martin Early Career Fellow
2019                Head, Diabetes and Metabolic Disease, SVI

Achievements

2008-11           International Postgraduate Research Scholarship (IPRS)
2008-11           Monash Graduate Scholarship (MGS)
2010                The Annual Research Conference (Monash University) – 1st prize
                        seminar winner
2012-13           Diabetes Australia Research Trust (DART) General Research Grant
2015-17           Chief Investigator (CIA) – NHMRC New Investigator Grant
2017                SVI Director’s Award – Most outstanding publication by a post-doc
2018                Australian Diabetes Society (ADS) Skip Martin Fellowship
2018-19           L.E.W. Carty Charitable Fund
2019                Diabetes Australia Research Trust (DART) General Research Grant
2019-21           Chief Investigator (CIA) – NHMRC Project Grant x 2

Research Interests

My research program aims to identify novel therapeutic targets for the treatment of metabolic diseases by exploiting my previous research discoveries on the biology of AMP-activated kinase (AMPK) and neuropeptide Y (NPY) system. My work aims to elucidate the role of AMPK in the regulation of cholesterol metabolism in immune cells and its implication in the development of atherosclerosis and diabetes-associated complications. In addition, my research also focuses on understanding the role of NPY system in pancreatic islet function and hepatic lipid metabolism, and to translate this new biochemical and phenotypic understanding into treatment for diabetes and fatty liver disease.

Selected Publications

  1.  KIM LOH*, Tam S, Murray-Segal L, Huynh K, Meikle PJ, Scott JW, Chen ZP, Steel R, LeBlond ND, Burkovsky LA, O’Dwyer C, Nunes JRC, Steinberg GR, Fullerton MD, Galic S and Kemp BE (2019) Inhibition of AMPK-HMGCR Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance. Hepatology Communications. 12;3(1):84-98 *Corresponding author.
  2. Galic S, KIM LOH, Murray-Segal L, Steinberg GR, Andrews Z, Kemp BE. (2018) AMPK signalling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis. eLife 2018:7:e32656
  3. KIM LOH*, Shi YC*, Walters S*, Bensellam M, Lee KL, Dezaki K, Nakata M, Gurzov E, Thomas HE, Waibel M, Cantley J, Kay TWH, Yada T, Laybutt RD, Grey S and Herzog H (2017) Inhibition of Y1 receptor signaling improves islet transplant outcome. Nature Communications. 8:490  *Co-first author
  4. Litwak S, Pang L, Galic S, Igoillo-Esteve M, Stanley WJ, Turatsinze JV, KIM LOH, Thomas HE, Sharma A, Trepo E, Moreno C, Gough DJ, Eizirik DL, de Haan JB and Gurzov EN (2017) JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis and Insulin Resistance in Obesity. Diabetes, 6:574-584
  5. KIM LOH*, Zhang L, Brandon A, Wang QP, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Bruning JC, Cooney G, Neely G and Herzog H (2017) Insulin controls food intake and energy balance via NPY neurons. Molecular Metabolism, 6:574-584 *Corresponding author.
  6. Dodd G, Descherf S, KIM LOH, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, and Tiganis T (2015) Leptin and insulin act on POMC neurons to promote browning of white fat. Cell. 160, 88-104
  7. KIM LOH, Herzog H, Shi YC (2015) Regulation of Energy Homeostasis by the NPY system. Trends in Endocrinology and Metabolism. 26(3), 125-135 *Featured Review
  8. Yulyaningsih E*, KIM LOH*, Lin S*, Lau J, Zhang L, Shi YC, Berning B, Enriquez R, Driessler F, Macia L, Khor E, Qi Y, Baldock P, Sainsbury A & Herzog H (2014) Pancreatic Polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism.19, 58-72 *Co-first author
  9. KIM LOH, Fukushima A, Zhang XM, Galic S, Briggs D, Enriori PJ, Simonds S, Weide F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, and Tiganis T (2011) Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metabolism. 14, 684-699
  10. KIM LOH, Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B.J., Skiba B., Ooms L., Stepto, N., Wu, B., Mitchell, C.A., Tonks, N.K., Watt, M.J., Febbraio, M.A., Crack, P.J., Andrikopoulos, S., and Tiganis, T. (2009) Reactive oxygen species enhance insulin sensitivity. Cell Metabolism. 10, 260-272
    *This manuscript was the Featured Article of the issue & an ‘Editor’s Choice’ article in Science Signaling