A/Prof Ramin Shayan

Research Unit

Lymphatic, adipose & regenerative medicine


Director, O’Brien Institute Department, SVI
Victorian Regional Council, Royal Australasian College of Surgeons
Co-Head, Lymphatic and Regenerative Surgery Group
Clinical Senior Lecturer, Department of Surgery, The University of Melbourne
Honorary Fellow, Department of Medicine, University of Melbourne
Honorary Fellow, Plastic Surgery Research Unit, Royal Melbourne Hospital, Department of Anatomy and Cell Biology, University of Melbourne
Port Phillip Council, Health and Wellbeing Grants Committee
Consultant, Organogenesis Inc., Canton, Massachusetts, USA

Professional Experience

2001     MBBS, University of Melbourne, Melbourne, Australia.
2004     Diploma of Surgical Anatomy, University of Melbourne
2009     PhD, Ludwig Institute for Cancer Research, University of Melbourne
2012     Fellowship in Plastic Surgery, Royal Australasian College of Surgeons
2013   Plastic Surgeon: St Vincent’s Hospital, Royal Melbourne Hospital, Alfred Hospital, Burns Unit, Alfred Hospital, Victorian Plastic Surgery Unit, St Vincent’s Private Hospital, (Honorary), Vascular Malformation Clinic, Royal Children’s Hospital


Research Interests

Lymphoedema; Lipoedema; Melanoma; Radiation Injury; Lymphatic Biology

Selected Publications

  1. Areeb Z, Stylli SS, Ware TM, Harris NC, Shukla L, Shayan R, Paradiso L, Li B, Morokoff AP, Kaye AH, Luwor RB. Inhibition of glioblastoma cell proliferation, migration and invasion by the proteasome antagonist carfilzomib. Med Oncol. 2016 May;33(5):53.
  2. Ross R, Shayan R, Mutimer, K.L., and Ashton, M.W. Autologous fat graft survival: current state of the art. Annals of Plastic Surgery (2015) 74(5):633-4.
  3. Shukla L,  Morrison WA, Shayan R. Adipose-derived stem cells in radiotherapy injury: a new frontier. Front. Surg., (2015) 28 January. doi: 10.3389/fsurg.2015.00001
  4. Herle P, Shukla L, Morrison WA, Shayan R. Preoperative radiation and free flap outcomes for head and neck reconstruction: a systematic review and meta-analysis. ANZ J Surg. (2015) 85(3):121-7.
  5. Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG. Lymphangiogenesis and lymphatic vessel remodeling in cancer. Nature Reviews Cancer (2014) Mar;14(3):159-72.
  6. Francois M, Karnezis T, Shayan R. Ordered Chaos: Harnessing Developmental Pathways in Tumor-Induced Lymphangiogenesis. J Clin Cell Immunol (2014) 5:270. doi: 10.4172/2155-9899.1000270
  7. Karnezis T, Shayan R. Lymphatic interactions and roles in cancer metastasis. Cancer Forum. (2014);38(2)97-102.
  8. Shayan R, Gill P, Mahar P, Karnezis T, Ashton MW, Grinsell D, Taylor I, Hunter-Smith D. Lymphatics and blood vessels in irradiated skin tissue. Aust J Dermatol. (2013) 54;S2, 47-48.
  9. Matsumoto M, Roufail S, Inder R, Caesar C, Karnezis T, Shayan R, Farnsworth RH, Sato T, Achen MG, Mann GB, Stacker SA. Signalling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis. Clin Exp Metastasis. (2013) Aug;30(6):819-32.
  10. Shukla, L., Taylor, G.I. and Shayan, R. The Pedicled Inferior Paraumbilical Perforator (I-PUP) Flap for a Volar Wrist Defect:  A Reconstructive Solution Across the Ages. J Plast Reconstr Aesthet Surg (2013) Nov;66(11):1623-5.
  11. Paquet-Fifield S, Levy S, Sato T, Shayan R, Karnezis T, Davydova N, Nowell CJ, Roufail S, Zhi-Ming Ma G, Zhang YF, Stacker SA and Achen MG. Vascular Endothelial Growth Factor-D Modulates Calibre And Function Of Initial Lymphatics In The Dermis. J Invest Dermatol. (2013) Aug;133(8):2074-84.
  12. Shayan, R., Inder, R., Karnezis, T., Caesar, C., Paavonen, K., Ashton, M.W., Mann, G.B., Taylor, G.I., Achen, M.G. and Stacker, S.A. Tumor location and nature of lymphatic vessels are key determinants of the metastatic spread of cancer. Clin Exp Metastasis (2013) Mar;30(3):345-56.
  13. Karnezis T, Shayan R, Fox S, Achen MG, Stacker SA. The connection between lymphangiogenic signalling and prostaglandin biology: A missing link in the metastatic pathway. Oncotarget. (2012) Aug;3(8):890-903. 
  14. Shayan, R., Karnezis, T., Murali, R., Wilmott , J., Ashton, M.W., Taylor, G.I., Thompson, J.F., Hersey, P., Achen, M.G., Scolyer, R.A. and Stacker, S.A. Lymphatic vessel density in primary melanomas predicts sentinel lymph node status and risk of metastasis. Histopathology, (2012) May 17;61(4):702-710. 
  15. Karnezis, T., Shayan, R., Caesar, C., Roufail, S., Ardipradja, K., Harris, N.C., Farnsworth, R.H., Williams, S.P., Zhang, Y., Ming, C., Fox, S., Sloan, E., Achen, M.G. and Stacker, S.A. VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium. Cancer Cell (2012);21, 181-195. 
  16. Farnsworth, R., Karnezis, T., Shayan, R., Matsumoto, M., Nowell, C., Achen, M. and Stacker S. A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growth. Cancer Res. (2011);71:6547-6557.
  17. Behan, F.C., Lo, C.H., Shayan, R. and Findlay M. The keystone technique for resolution of chronic lower limb wound with lymphoedema. J Plast Reconstr Aesthet Surg. (2009) May;62(5):701-2.
  18. Shayan, R., Rozen, W.M., Bernard, S., Corlett, R.J., Ashton, M.W., Taylor, G.I. Perforator dilatation induced by bodyweight gain is not reversed by subsequent weight loss: implications for perforator flaps. Plast Reconstr Surg. (2008) Dec;122(6):1765-72.|
  19. Francois, M., Caprini, A., Hosking, B., Orsenigo, F., Wilhelm, D., Browne, C., Paavonen, K., Karnezis, T., Shayan, R., Downes, M., Davidson, T., Tutt, D., Cheah, K.S.E., Stacker, S.A., Muscat G.E.O., Achen, M.G., Dejana, E. and Koopman, P. Sox18 induces development of the lymphatic vasculature in mice. Nature (2008) Dec 4;456(7222):643-7.
  20. Shayan, R., Karnesis, T., Achen, M. G., Mann, G. B., Stacker, S. A. and Taylor, G. I. The nature of nearby lymphatics dictate whether vascular endothelial growth factor-D (VEGF-D) induces tumor lymphatic’s and metastasis. ANZ J Surg. (2007) May;77(s1):A87
  21. Stacker, S.A., Farnsworth, R.H., Karnezis, T., Shayan, R., Smith, D.P., Paavonen, K., Davydova, N., Caesar, C., Inder, R., Baldwin, M.E., McColl, B.K., Roufail, S., Williams, R.A., Hughes, R.A., Alitalo, K., Achen, M.G. Molecular pathways for lymphangiogenesis and their role in human disease. Novartis Found Symposium (2007);281:38-43.
  22. Shayan, R., Karnezis, T., Tsantikos, E., Williams, S.P., Runting, A.S., Ashton, M.W., Achen, M.G., Hibbs, M.L. and S.A. Stacker. A system for quantifying the patterning of the lymphatic vasculature, Growth Factors (2007) Dec;25(6):417-25.
  23. Shayan, R., Achen, M.G. and Stacker, S.A. Lymphatic vessels in cancer metastasis: bridging the gaps. Carcinogenesis (2006) Sep;27(9):1729-38.