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Dr Rohan Bythell-Douglas

Research Unit

Genome stability

Information

Post-doctoral Research Officer

Professional Experience

2018 – present        Postdoctoral research officer, St Vincent’s Institute of Medical
                                Research
2015 – 2017            Postdoctoral training fellow, Chromatin Remodelling studies, 
                                Imperial College, London
2014 – 2015            Postdoctoral training fellow, Chromatin Remodelling studies,
                                Institute of Cancer Research, London
2013                        PhD Chemistry, University of Western Australia
2009                        BSc Chemistry and Genetics (1st class Hons), University of
                                Western Australia

Achievements

July 2014              Mel Greaves Science Writing Prize - Institute of Cancer
                             Research science communication competition
July 2013              UWA PhD Completion Scholarship
March 2010          Australian Postgraduate Award Scholarship (3.5 years)

Research Interests

DNA damage repair and chromatin remodelling. Protein structure.

Selected Publications

  1. R. J. Aramayo, O. Willhoft, R. Ayala, R. Bythell-Douglas, D. B. Wigley, X. Zhang. (2018). Cryo-EM structures of the human INO80 chromatin-remodeling complex. Nature structural & molecular biology 25 (1), 37.
  2. D. M. Rees, O. Willhoft, C. L. Lin, R. Bythell-Douglas, D. B. Wigley. (2017). Production and Assay of Recombinant Multisubunit Chromatin Remodeling Complexes. Methods in enzymology 592, 27-47.
  3. R. Bythell-Douglas, C. J. Rothfels, D. W. D. Stevenson, S. W. Graham, G. K. Wong, D. C. Nelson, T. Bennett. (2017). Evolution of strigolactone receptors by gradual neo-functionalization of KAI2 paralogues. BMC biology 15 (1), 52.
  4. O. Willhöft*, R. Bythell-Douglas*, E. A. McCormack, D. B. Wigley. (2016). Synergy and antagonism in regulation of recombinant human INO80 chromatin remodeling complex. Nucleic Acids Res. doi: 10.1093/nar/gkw509. *First authors.
  5. M. Lopez-Obando, C. E. Conn, B. Hoffmann, R. Bythell-Douglas, D. C. Nelson, C. Rameau, S. Bonhomme. (2016). Structural modeling and transcriptional responses highlight a clade of pPKAI2-LIKE genes as candidate receptors for strigolactones in Physcomitrella patens. Planta. 243(6):1441-53.
  6. C. E. Conn, R. Bythell-Douglas, D. Neumann, S. Yoshida, B. Whittington, J. H. Westwood, K. Shirasu, C. S. Bond, K. A. Dyer, D. C. Nelson. (2015). Convergent evolution of strigolactone perception enabled host detection in parasitic plants. Science. 349(6247):540-3.
  7. R. Bythell-Douglas, U. Suttisansanee, G. R. Flematti, M. Challenor, M. Lee, S. Panjikar, J. F. Honek, C. S. Bond. (2015). The crystal structure of a homodimeric Pseudomonas glyoxalase I enzyme reveals asymmetric metallation commensurate with half-of-sites-activity. Chem - Eur J. 21(2), 541-4.
  8. R. Bythell-Douglas, M. T. Waters, A. Scaffidi, G. R. Flematti, S. M. Smith, C. S. Bond. (2013). The structure of the karrikin-insensitive protein (KAI2) in Arabidopsis thaliana. PLoS One. 8(1):e54758.