Dr Rohan Bythell-Douglas

Research Unit

Genome stability


Post-doctoral Research Officer

Professional Experience

2018 – present Postdoctoral research officer, St Vincent’s Institute of Medical Research
2015 – 2017 Postdoctoral training fellow, Chromatin Remodelling studies. Imperial College, London
2014 – 2015 Postdoctoral training fellow, Chromatin Remodelling studies. Institute of Cancer Research, London
2013 PhD Chemistry, University of Western Australia
2009 BSc Chemistry and Genetics (1st class Hons), University of Western Australia


July 2014 Mel Greaves Science Writing Prize - Institute of Cancer research science communication competition.
July 2013 UWA PhD Completion Scholarship
March 2010 Australian Postgraduate Award Scholarship (3.5 years)

Research Interests

DNA damage repair and chromatin remodelling. Protein structure.

Selected Publications

  1. R. J. Aramayo, O. Willhoft, R. Ayala, R. Bythell-Douglas, D. B. Wigley, X. Zhang. (2018). Cryo-EM structures of the human INO80 chromatin-remodeling complex. Nature structural & molecular biology 25 (1), 37.
  2. D. M. Rees, O. Willhoft, C. L. Lin, R. Bythell-Douglas, D. B. Wigley. (2017). Production and Assay of Recombinant Multisubunit Chromatin Remodeling Complexes. Methods in enzymology 592, 27-47.
  3. R. Bythell-Douglas, C. J. Rothfels, D. W. D. Stevenson, S. W. Graham, G. K. Wong, D. C. Nelson, T. Bennett. (2017). Evolution of strigolactone receptors by gradual neo-functionalization of KAI2 paralogues. BMC biology 15 (1), 52.
  4. O. Willhöft*, R. Bythell-Douglas*, E. A. McCormack, D. B. Wigley. (2016). Synergy and antagonism in regulation of recombinant human INO80 chromatin remodeling complex. Nucleic Acids Res. doi: 10.1093/nar/gkw509. *First authors.
  5. M. Lopez-Obando, C. E. Conn, B. Hoffmann, R. Bythell-Douglas, D. C. Nelson, C. Rameau, S. Bonhomme. (2016). Structural modeling and transcriptional responses highlight a clade of pPKAI2-LIKE genes as candidate receptors for strigolactones in Physcomitrella patens. Planta. 243(6):1441-53.
  6. C. E. Conn, R. Bythell-Douglas, D. Neumann, S. Yoshida, B. Whittington, J. H. Westwood, K. Shirasu, C. S. Bond, K. A. Dyer, D. C. Nelson. (2015). Convergent evolution of strigolactone perception enabled host detection in parasitic plants. Science. 349(6247):540-3.
  7. R. Bythell-Douglas, U. Suttisansanee, G. R. Flematti, M. Challenor, M. Lee, S. Panjikar, J. F. Honek, C. S. Bond. (2015). The crystal structure of a homodimeric Pseudomonas glyoxalase I enzyme reveals asymmetric metallation commensurate with half-of-sites-activity. Chem - Eur J. 21(2), 541-4.
  8. R. Bythell-Douglas, M. T. Waters, A. Scaffidi, G. R. Flematti, S. M. Smith, C. S. Bond. (2013). The structure of the karrikin-insensitive protein (KAI2) in Arabidopsis thaliana. PLoS One. 8(1):e54758.