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Dr Sandra Galic

Research Unit

Protein chemistry & metabolism

Information

Senior Research Officer
Protein Chemistry and Metabolism Unit

Professional Experience

2001     Biochemistry graduate, University of Tübingen, Germany
2008     PhD, Monash University, Clayton

Achievements

2002     International Postgraduate Research Scholarship
2002     Monash Graduate Scholarship

Research Interests

Role of AMPK in lipid and glucose metabolism; obesity and type 2 diabetes; inflammation and insulin resistance; central regulation of food intake and body weight; AMPK knockout mouse models

Selected Publications

  1. Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR (2013) Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin Nature Medicine, 19(12), 1649 – 1654 (co-first author).
  2. Palanivel R, Fullerton MD, Galic S, Honeyman J, Hewitt KA, Jorgensen SB, Steinberg GR (2012) Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance. Diabetologia 55(11), 3083 – 3093
  3. Loh K, Merry TL, Galic S, Wu BJ, Watt MJ, Zhang S, Zhang ZY, Neel BG, Tiganis T (2012) T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signaling and glucose homeostasis in mice. Diabetologia, 55(2), 468 – 478
  4. Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T (2011) Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metabolism,14(5), 684 – 699
  5. Galic S, Fullerton MD, Schertzer JD, Sikemma S, Marcinko K, Walkley CR, Izon D, Honeyman J, Chen ZP, van Denderen BJ, Kemp BE, Steinberg GR (2011) Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage  inflammation and insulin resistance in obesity. Journal of Clinical Investigation, 121(12) 4903 – 4915
  6. Sachithanandan N, Grahame KL, Galic S, Honeyman JE, Fynch SL, Hewitt KA,  Steinberg GR, Kay TW (2011) Macrophage deletion of SOCS1 increases senstivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance. Diabetes, 60(8), 2023 -2031
  7. Fukushima A, Loh K, Galic S, Fam B, Shields B, Wiede F, Tremblay ML, Watt MJ, Andrikopolous S, Tiganis T (2010) T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. Diabetes 59(8), 1906 – 1914
  8. Steinberg GR, O'Neill HM, Dzamko NL, Galic S, Naim T, Koopman R, Jorgensen SB, Honeyman J, Hewitt K, Chen ZP, Schertzer JD, Scott JW, Koentgen F, Lynch GS, Watt MJ, van Denderen BJ, Campbell DJ, Kemp BE (2010) Whole-body deletion of AMP-activated protein kinase beta2 reduces muscle AMPK activity and exercise capacity. Journal of Biological Chemistry 285(48), 37198 – 37209