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UP

Dr Shiang (Max) Lim

Research Unit

Cardiac regeneration

Information

Senior Research Officer
Head, Cardiac Regeneration Group

Professional Experience

2010       Senior Research Officer, The O’Brien Institute, Australia
2010       Honorary fellow, Department of Surgery, University of Melbourne
2005-10  Post-doctoral fellow, The Hatter Cardiovascular Institute, UCL, UK
2005       PhD in Physiology and Pharmacology, University of Strathclyde, UK
2002       Master in Pharmacy, University of Strathclyde, UK

Achievements

2012       HBPRCA Young Investigator Award
2012       APSH Young Investigator Fellowship
2002       Overseas Research Scholarship

Research Interests

Cardiac repair and regeneration, stem cell cardiac differentiation and secretomes, cardiac tissue engineering, roles of mitochondrial morphology in cell survival and cardiogenesis.

Selected Publications

  1. Rosdah AA, Holien JK, Delbridge LMD, Dusting GJ, Lim SY. Mitochondrial fission – a drug target for cytoprotection or cytodestruction? Pharmacol. Res. Prespective. 2016:4:e00235
  2. Khanabdali R, Rosdah A, Dusting GJ, Lim SY. Harnessing the secretome of cardiac stem cells as therapy for treat ischaemic heart disease. Biochem. Pharmcol. 2016 (Epub Feb 21)
  3. Chan EC, Kuo SM, Kong AM, Morrison WA, Dusting GJ, Mitchell GM, Lim SY*, Liu GS*. Three dimensional collagen scaffold promotes intrinsic vascularisation for tissue engineering applications. Plos one. 2016:11(2):e0149799. *equal authors
  4. Hernández D, Millard R, Sivakumaran P, Wong RCB, Crombie DE, Hewitt AW, Liang H, Hung SSC, Pébay A, Shepherd RK, Dusting GJ, Lim SY. Electrical stimulation promotes cardiac differentiation of human induced pluripotent stem cells. Stem Cell International. 2016:1718041
  5. Zhang Y, Sivakumaran P, Newcomb AE, Hernandez D, Harris N, Khanabdali R, Liu GS, Kelly DJ, Pébay A, Hewitt AW, Boyle A, Harvey R, Morrison WA, Elliott DA, Dusting GJ, Lim SY. Cardiac repair with a novel population of mesenchymal stem cells resident in the human heart. Stem Cells. 2015:33:3100-3113.
  6. Hsiao ST, Dilley RJ, Dusting GJ, Lim SY. Ischemic preconditioning for cell-based therapy and tissue engineering. Pharmacology Therapeutics. 2013:142:141-153. 
  7. Lim SY, Sivakumaran P, Crombie D, Dusting GJ, Pébay A, Dilley RJ. Trichostatin-A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. Stem Cells Transl. Med. 2013:2:715-725
  8. Hsiao ST, Lokmic Z, Peshavariya H, Sivakumaran P, Dusting GJ, Abberton K, Lim SY*, Dilley RJ*. Hypoxia enhanced angiogenic paracrine activity of human adipose-derived stem cells. Stem Cell Dev. 2013:22:1614-1623. *equal authors
  9. Lim SY, Hausenloy DJ. Remote ischemic conditioning: from bench to bedside. Frontiers in Clinical Translational Physiology. 2012:3:27
  10. Lim SY, Hausenloy DJ, Arjun S, Price AN, Davidson SM, Lythgoe MF, Yellon DM. Mitochondria cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure. J. Cell. Mol. Med. 2011:15:2443-2451.
  11. Ong SB, Subrayan S, Lim SY, Yellon DM, Davison SM, Hausenloy DJ. Inhibiting mitochondrial fission protects the heart against ischemia reperfusion injury. Circulation. 2010:121: 2012-2022.