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Dr Tara Karnezis

Research Unit

Lymphatic & regenerative surgery

Information

Group Leader, Lymphatic and Regenerative Surgery Group, O’Brien Institute Department, SVI

Professional Experience

1996         BSc (Hons), La Trobe University
1997-01    Demonstrator, Dep of Biochemistry, La Trobe University
2002         PhD, Depts of Biochemistry and Genetics, La Trobe University
2003-04   Postdoctoral Research Fellow, Dept of Neurology and Neurological
                  Sciences, Stanford
2005-10    Research Fellow, Ludwig Institute for Cancer Research
2010-15    Senior Research Fellow, Angiogenesis Program, Peter MacCallum
                 Cancer Centre
2016         Group Leader, Lymphatic and Regenerative Surgery, OBI Dept, SVI

Achievements

1993     Deans Commendation
1994     La Trobe University Prize, Top 2nd Year Student in Microbiolgy
1994     Australian Society for Microbiology Prize
1995     Australian Society for Microbiology Prize
1995     Unitika Biochemistry Prize
1996     Peter MacCallum Summer Studentship
1997     PhD Industry Scholarship
2000    ASBMB Travel Fellowship
2003    Stanford University Post-doctoral Fellowship
2010    CASS Foundation Travel Fellowship
2013    Finalist, Peter MacCallum Translate Prize

Research Interests

Lymphatic Biology; Genetics of Lymphatic Disease: Lymphoedema and Lipoedema; Radiation Injury following Cancer

Selected Publications

  1. Karnezis T, Mandemaker W, McQualter JL, Binhai Z, Ho PP, Jordan KA, Murray BM, Barres B, Tessier-Lavigne M and Bernard CCA (2004). The neurite outgrowth inhibitor NogoA is involved in autoimmune-mediated demyelination. Nature Neuroscience 7:736-744.
  2. Fai H, Karnezis T, Reimer RJ, Krantz DE (2007)  Membrane topology of the   Drosophila vesicular glutamate transporter. Journal of Neurochemistry 101(6):1662-71
  3. McColl BK, Paavonen K, Karnezis T, Roufail S, Rogers P, Alitalo K, Stacker SA, Achen MG (2007).  Pro-protein convertases promote activation of the lymphangiogenic protein vascular endothelial growth factor-D. FASEB Journal 21(4):1088-98.
  4. Francois M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne K, Paavonen K, Karnezis T, Shayan R, Downes M, Davidson T, Desmond T, Cheah KS, Stacker SA, Muscat G, Achen MG, Dejana E, Koopman P (2008). Sox18 induces development of the lymphatic vasculature in mice. Nature 4:643-7.
  5. Weber M, Prod’homme T, Karnezis T, Patarroyo J, Rundle C, Danilenko D, Slavin A, Linington C, Bernard C, Martin F, Zamvil S (2010).  Anti-CD20 B-cell depletion in immune intervention of central nervous system autoimmune disease. Annals of Neurology 68:369-383.
  6. Harris NC, Paavonen K, Davydova N, Roufail S, Sato T, Zhang YF,  Karnezis T, Stacker SA and Achen MG (2011). The proteolytic processing of VEGF-D is essential for its capacity to promote the growth and spread of cancer.  FASEB J. 25;8:2615-25.
  7. Karnezis T, Shayan R, Caesar C, Roufail S, Harris NC, Ardipradja KL, Zhang YF,  Williams SP, Farnsworth RH, Chai MC, Rupasinghe T, Tull D, Baldwin ME,  Sloan EK,  Fox SB, Achen MA, Stacker SA (2012). VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium. Cancer Cell 21(2):181-95.
  8. Karnezis T, Shayan R, Fox S, Achen MG, Stacker SA (2012). The connection between lymphangiogenic signalling and prostaglanding biology: A missing link in the metastatic pathway. Oncotarget 3(8):893-906.
  9. Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG. (2014). Lymphangiogenesis and Lymphatic vessel remodelling in cancer. Nature Reviews Cancer 14(3):159-72.
  10. Le CP, Nowell CJ, Kim-Fuchs C, Botteri E, Hiller JG, Ismail H, Pimentel MA, Chai MG, Karnezis T, Rotmensz N, Renne G, Gandini S, Pouton CW, Ferrari D, Moller A, Stacker SA, Sloan EK (2016). Chronic stress in mice remodels lymph vasculature to promote tumor cell dissemination. Nature Communications  7: 10634