scroll
UP

Dr Kevin Ngoei

Research Unit

Protein chemistry & metabolism

Information

Research Officer, Protein Chemistry and Metabolism Unit

Professional Experience

2008    BSc (Hons), Dept of Biochemistry & Molecular Biology, University of Melbourne.
2014    PhD, Dept of Biochemistry & Molecular Biology, University of Melbourne.
2014-   Research Officer, Protein Chemistry and Metabolism Unit, SVI

Achievements

2010    Melbourne International Research Scholarship
2012    Melbourne Research Scholarship
2013    ASBMB Fellowship
2016    SVI Foundation Travel Fellow
2016    SVI Director’s award – Most Outstanding Publication by a Post-doctoral Researcher
2017    Harold Mitchell Foundation Fellow

Research Interests

Protein kinase structure and function; signal transduction in modulation of energy metabolism; regulation of AMPK by small-molecule drugs and metabolites; development of novel drugs targeting allosteric sites of AMPK.

Selected Publications

  1. Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KR, Langendorf CG, O’Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS. (2017) “The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs” Nat Commun. in press.
  2. Langendorf CG*, Ngoei KR*, Scott JW, Ling NXY, Issa SMA, Gorman MA, Parker MW, Sakamoto K, Oakhill JS, Kemp BE. (2016) Structural basis of furan-2- phosphonic derivative (C2) binding and isoform selectivity in allosteric and synergistic activation of AMPK. Nat Commun.7:10912.
  3. Annesley SJ, Lay ST, De Piazza SW, Sanislav O, Hammersley E, Allan CY, Francione LM, Bui MQ, Chen ZP, Ngoei KR, Tassone F, Kemp BE, Storey E, Evans A, Loesch DZ, Fisher PR. (2016) “Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity” Dis Model Mech. 9(11):1295-1305.
  4. Misheva M, Kaur G, Ngoei KR, Yeap YY, Ng IH, Wagstaff KM, Ng DC, Jans DA, Bogoyevitch MA. (2014) “Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress” Biochim Biophys Acta. 1843(2): 253-264.
  5. Ngoei KR, Catimel B, Milech N, Watt PM & Bogoyevitch MA. (2013) “A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor” Int J Biochem Cell Biol. 45(8): 1939-1950.
  6. Ngoei KR, Ng DC, Gooley PR, Fairlie DP, Stoermer MJ & Bogoyevitch MA. (2013) “Identification and characterization of bi-thiazole-2,2’-diamines as kinase inhibitory scaffolds” Biochim Biophys Acta.  1834(6): 1077-1088.
  7. Bogoyevitch MA, Yeap YY, Qu Z, Ngoei KR, Yip YY, Zhao TT, Heng JI & Ng DC. (2012) “WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression” J. Cell Sci.  125(Pt.21): 5096-5109.
  8. Ngoei KR, Catimel B, Church N, Lio DS, Dogovski C, Perugini MA, Watt PM, Cheng HC, Ng DC & Bogoyevitch MA. (2011) “Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide” Biochem. J.  434, 399-413.
  9. Ng DC, Zhao TT, Yeap YY, Ngoei KR & Bogoyevitch MA. (2010) “c-Jun N- terminal kinase phosphorylation of stathmin confers protection against cellular stress” J. Biol. Chem. 285, 29001-13.
  10. Bogoyevitch MA, Ngoei KR, Zhao TT, Yeap YY, Ng DC. (2010) “c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges” Biochim. Biophys. Acta 1804, 463-75.