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Dr Musarat Ishaq

Research Unit

Lymphatic, adipose & regenerative medicine

Information

Senior Research Scientist
Lymphatics & Regenerative Medicine

Professional Experience

2016-present        Senior Scientist, St Vincent Institute of Medical Research (SVI),
                             Melbourne Australia
2015-2016            Postdoctoral Research Officer, Tumor Angiogenesis Laboratory,
                             Peter Maccullum Cancer Centre, Melbourne Australia
2012-2015            OCE Research Fellow, Commonwealth Scientific and Industrial
                             Research Organization (CSIRO), Sydney Australia
2011-2012            Postdoctoral Fellow, Department of Molecular Bioscience,
                             Stockholm University, Stockholm Sweden
2008-2010           Postdoctoral fellow, Department of Chemical and Biological
                             Engineering, University of Wisconsin-Madison, Madison WI USA
2005-2008           PhD Microbiology/Virology, College of Life Sciences,
                             Wuhan University, Wuhan China

Achievements

Research Interests

Lipoedema is a poorly understood chronic disease of adipose tissues. We are interested to explore the molecular mechanism involved in disease development at molecular and genetics levels. We are employing “OMICS” technologies to find molecular targets which can help for diagnostic and therapeutic development.

Selected Publications

  1. Musarat Ishaq et al. (2013) Effects of atmospheric gas plasmas on cancer cell signaling. International Journal of Cancer; 134 (7): 1517-1528
  2. Musarat Ishaq et al. (2014) Atmospheric gas plasma-induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis. Molecular Biology of the Cell; 25 (1): 1523-1531.
  3. Musarat Ishaq et al. (2014) Atmospheric-pressure gas plasma–induced colorectal cancer cell death mediated by Nox2-ASK1 apoptosis pathways and oxidative stress mitigated by Srx-Nrf2 anti-oxidant system. BBA:Molecular Cell Research; 1843 (2014) 2827-2837.
  4. Musarat Ishaq et al (2015) Atmospheric pressure gas plasmas and TRAIL induce apoptosis in TRAIL-resistant colorectal cancer cells through death receptor 5 and ROS mediated signaling pathway. Plasma Process & Polymer 12(6) 572-582
  5. Musarat Ishaq, Ma Li, et al, The DEAD-box RNA helicase DDX1 interacts with NF-kB subunit RelA/p65 and enhances NF-kB mediated transcription. J Cell Biochem. 1;106(2), 296-305 (2009) (IF :3.075)
  6. Musarat Ishaq et al., (2016) Effect of atmospheric plasmas on drug resistant melanoma: the challenge of translating in vitro outcomes into animals models. Plasmas Medicine Journal DOI: 10.1615/PlasmaMed.2016015867.
  7. Musarat Ishaq et al (2015) Pro-apoptotic NOXA is implicated in atmospheric-pressure plasma-induced melanoma cell death  Journal of Physics D: Applied Physics, 48 (46)
  8. Musarat Ishaq et al (2015) Intracellular effects of atmospheric-pressure plasmas on melanoma cancer cells, Phys. Plasmas 22, 122003 
  9. Musarat Ishaq et al, Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis. Mol Biotechnol. 39(3), 231-238 (2008).
  10. Davydova N, Harris NC, Roufail S, Paquet-Fifield S, Ishaq M, Strelstov VA, Williams SP, Karnezis T, Stacker SA and Achen MG (2016). Differential receptor binding and regulatory mechanisms for the lymphangiogenic growth factors VEGF-C and VEGF-D. Journal of Biological Chemistry 291:27265
  11. Z. Xiong, S. Zhao, X. Mao, X. Lu, G. He, G. Yang, M. Chen, Musarat Ishaq, K Ostrikov (2014) Selective neuronal differentiation of neural stem cells induced by nanosecond microplasma agitation. Stem Cell Research 12 (2), 387-399.
  12. Zhao Jun Han, Amanda Rider, Musarat Ishaq, Shailesh Kumar, Alexey Kondyurin, Marcela M. M. Bilek, Igor Levchenko and Kostya (Ken) Ostrikov, Carbon nanostructures for hard tissue engineering. RSC Advances, 2013 (3), 11058.
  13. Yongxin Mu, Yi Yu, Xin Yue, Musarat Ishaq et al, The X protein of HBV induces HIV-1 long terminal repeat transcription by enhancing the binding of C/EBPβ and CREB1/2 regulatory proteins to the long terminal repeat of HIV-1. Virus Res. 156(1-2), 81-90 (2011).
  14. Hu Tao, Chen Ping, Fu Qiong, Musarat Ishaq et al, Comparative studies of various artificial microRNA expression vectors for RNAi in mammalian cells. Mol Biotechnol 46(1), 34-40 (2010).
  15. Xiaoyun WU, Guozhen GAO, Musarat Ishaq, et al. M2 pyruvate kinase enhances HIV-1 transcription from its long terminal repeat [J]. Front. Biol., 2010, 5(1): 59-66.
  16. Junwei Li, Musarat Ishaq, Mabiala Prudence et al, "Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2".  Virus Res. 144(1-2), 123-9 (2009).
  17. Xiaoyun Wu, Musarat Ishaq, et al, HCV NS3/4A protein activates HIV-1 transcription from its long terminal repeat 1. Virus Res. 135(1), 155-160 (2008).
  18. Ji'An Pan, Xiaoxue Peng, Yajing Gao, Zhilin Li, Xiaolu Lu, Yingzhao Chen, Musarat Ishaq, et al Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication. PLoS ONE 10(3), e3299 (2008).