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UP

Prof Bruce E. Kemp

Research Unit

Protein chemistry & metabolism

Information

Pehr Edman Fellow
Professorial Associate
Department of Medicine, The University of Melbourne, St Vincent's Hospital

Professional Experience

1970              BAgSci (Hons), Adelaide University
1975              PhD (Flinders)
1988-04        Deputy Director, St Vincent's Institute
1980-84        NHMRC Fellow, Howard Florey Institute
1985-88        University Melbourne, Repatriation General Hospital, Heidelberg

Achievements

1988     Selwyn Smith Prize for Medical Research
1989     Newman Award for Excellence in AIDS Research (shared award)
1989     AIDS Trust of Australia Award
1990     Pharmacia-L.K.B. Medal and Travelling Fellowship Award
1990     The Wellcome Australia Medal for Medical Research and Technology
              Development
1991     The Wellcome Rapid Diagnostics Award
1996     Lemberg Medal, ASBMB
1996     The Royal Society of Victoria Research Medal, Biological Sciences
2000     Fellow Australian Academy of Science
2000     Max Planck Award
2002     Fellow Royal Society UK
2003     Federation Fellow
2003     Centenary Medal (Australia)

Research Interests

Protein phosphorylation, instrasteric regulation, peptide substrates and inhibitors, AMP activated protein kinase (AMPK)
Protein Phosphorylation
How protein phosphorylation regulates protein function, and how AMP activated protein kinase regulates metabolic and gene transcriptional responses to exercise and metabolic stress. Drug design to increase exercise capacity and reduce age onset diseases. The fat/vanity pill, exercise in a pill.
Obesity, diabetes endurance performance, drug design
Medline listings 354, Papers in Science 9, Nature 5, Nature Medicine, 2 and Cell Metabolism 3. Career citations (ISI), >29,000, average per paper, 81.55 and H-index = 90. Listed by ISI under highly cited in Biology & Biochemistry and listed under Essential Science Indicators. The first and seventh most cited papers in Australian Medical Research (Analysis of the impact of Australian biomedical research by Bourke and Butler ("The Research Enterprise: Mapping Australia's basic research in the medical and health sciences" Medical Journal of Australia 167: 610-3, 1997)

Selected Publications

  1. Scott JW, Ling NXY, Issa SMA, Dite TA, O’Brien MT, Chen ZP, Galic S, Langendorf CG, Steinberg GR, Kemp BE, and Oakhill JS.  Drugs and AMP unite to switch on naive AMPK.  Chemistry and Biology.  2014, May 22;21(5):619-27.
  2. Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z. P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., Hardie, D. G., Macaulay, S. L., Schertzer, J. D., Dyck, J. R., van Denderen, B. J., Kemp, B. E. & Steinberg, G. R. 2013. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med, 19, 1649-54.
  3. Kemp, B.E., Pearson, R.B., Guerriero Jr., V., Bagchi, I.C. and Means, A.R. 1987. The calmodulin-binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. J. Biol. Chem., 262, 2542-2548.
  4. House, C. and Kemp, B.E. 1987. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science, 238, 1726-1728.
  5. Kemp, B.E., Moseley, J.M., Rodda, C.P., Ebeling, P.R., Wettenhall, R.E.H., Stapleton, D., Diefenbach-Jagger, H., Ure, F., Michelangeli, V.P., Simmons, H.A., Raisz, L.G. and Martin, T.J. 1987. Parathyroid hormone-related protein of humoral hypercalcemia of malignancy: biologically active synthetic fragments. Science, 238, 1568-1570.
  6. Pearson, R.B., Wettenhall, R.E.H., Means, A.R., Hartshorne, D.J. and Kemp, B.E. 1988. Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. Science, 241, 970-973.
  7. Oakhill JS, Chen ZP, Scott JW, Steel R, Castelli LA, Ling N, Macaulay SL, Kemp BE. β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19237-41.
  8. Hu, S-H., Parker, M.W., Lei, J.Y., Wilce, M.C.J., Benian, G.M. and Kemp, B.E. Insights into autoregulation from the crystal structure of twitchin kinase. Nature, 369, 581-584, 1994.
  9. Mitchelhill, K.I., Stapleton, D., Gao, G., House, C., Michell, B., Katsis, F., Witters, L.A. and Kemp, B.E. 1994. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J. Biol. Chem., 269, 2361-2364.
  10. Chen, Z-P, Mitchelhill, K.I., Michell, B.J., Stapleton, D., Rodriguez-Crespo, I. Witters, L.A., Power, D.A., Oritz de Montellano, P.R. and Kemp, B.E. 1994. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett. 443, 285-289.
  11. Steinberg, GR & Kemp, BE. 2009. AMPK in Health and Disease. Physiol Rev, 89, 1025-78.
  12. Oakhill JS, Chen ZP, Scott JW, Steel R, Castelli LA, Ling N, Macaulay SL, Kemp BE. β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). 2010. Proc Natl Acad Sci U S A. 107:19237-41.
  13. Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, Kemp BE. AMPK is a direct adenylate charge-regulated protein kinase. Science. 2011 Jun 17; 332: 1433-5.
  14. Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR. 2013. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med. 1649-54.
  15. Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG. 2012. The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 336 :918-22.
  16. Scott, J. W., Ling, N., Issa, S. M., Dite, T. A., Obrien, M. T., Chen, Z. P., Galic, S., Langendorf, C. G., Steinberg, G. R., Kemp, B. E. & Oakhill, J. S. 2014. Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling. Chem Biol. 21:1-9.